Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

被引：60
|
作者：
Shin, Hyoseung [1 ]
Yoo, Hyeon Gyeong [1 ]
Inui, Shigeki [2 ]
Itami, Satoshi [2 ]
Kim, In Gyu [3 ]
Cho, A-Ri [1 ]
Lee, Dong Hun [1 ]
Park, Won Seok [4 ]
Kwon, Ohsang [1 ]
Cho, Kwang Hyun [1 ]
Won, Chong Hyun [5 ]
机构：
[1] Seoul Natl Univ, Coll Med, Inst Human Environm Interface Biol, Dept Dermatol, Seoul 110744, South Korea
[2] Osaka Univ, Grad Sch Med, Dept Regenerat Dermatol, Osaka 5650871, Japan
[3] Seoul Natl Univ, Coll Med, Dept Biochem & Mol Biol, Seoul 110744, South Korea
[4] AmorePacific R&D Ctr, Pharmaceut Res Inst, Gyeonggi Do 446729, South Korea
[5] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Dermatol, Seoul 138736, South Korea
来源：
BMB REPORTS | 2013年 / 46卷 / 09期
关键词：
Androgenetic alopecia; Androgen receptor; Dermal papilla; Reactive oxygen species; Transforming growth factors; ALOPECIA; TESTOSTERONE; SCALP; METABOLISM; TGF-BETA-1; RECEPTORS; CONTAIN;
D O I：
10.5483/BMBRep.2013.46.9.228
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-beta 1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-beta 1 secretion is increased by androgen treatment in DP-6, whereas androgen-inducible TGF-beta 1 was significantly suppressed by the ROS-scavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-beta 1 by androgen is mediated by ROS in hair follicle DPCs.
引用
收藏
页码：460 / 464
页数：5
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