The biology of Hodgkin's lymphoma

被引：477

作者：

Kueppers, Ralf ^{[1
]}

机构：

[1] Univ Duisburg Essen, Sch Med, Inst Cell Biol Tumour Res, D-45122 Essen, Germany

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 01期

关键词：

REED-STERNBERG CELLS; EPSTEIN-BARR-VIRUS; CENTER B-CELLS; ANAPLASTIC LARGE-CELL; FACTOR-KAPPA-B; PERIPHERAL-BLOOD LYMPHOCYTES; RECEPTOR TYROSINE KINASES; FUNCTIONAL CD30 LIGAND; REGULATORY T-CELLS; MEMBRANE-PROTEIN;

D O I：

10.1038/nrc2542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however, remained enigmatic for along time. Only within the past 10 years has the B-cell nature of the pathognomonic Hodgkin and Reed-Sternberg (HRS) cells been revealed, along with several recurrent genetic lesions. The pathogenetic role for Epstein-Barr virus infection has also been substantiated. HRS cells in classical Hodgkin's lymphoma have several characteristics that are unusual for lymphoid tumour cells, and the Hodgkin's lymphoma microenvironment is dominated by an extensive mixed, potentially inflammatory cellular infiltrate. Understanding the contribution of all of these changes to the pathogenesis of this disease is essential for the development of novel therapies.

引用

页码：15 / 27

页数：13

共 164 条

[1]

Aguilera NSI, 2006, ARCH PATHOL LAB MED, V130, P1772

[2] MOLECULAR MIMICRY OF THE ANTIGEN RECEPTOR SIGNALING MOTIF BY TRANSMEMBRANE PROTEINS OF THE EPSTEIN-BARR-VIRUS AND THE BOVINE LEUKEMIA-VIRUS [J].

ALBER, G ;

KIM, KM ;

WEISER, P ;

RIESTERER, C ;

CARSETTI, R ;

RETH, M .

CURRENT BIOLOGY, 1993, 3 (06) :333-339

[3] Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells [J].

Aldinucci, D ;

Lorenzon, D ;

Olivo, K ;

Rapanà, B ;

Gattei, V .

LEUKEMIA & LYMPHOMA, 2004, 45 (09) :1731-1739

[4]

Aldinucci D, 2003, AM J PATHOL, V162, P356

[5] Expression of functional interieukin-3 receptors on Hodgkin and Reed-Sternberg cells [J].

Aldinucci, D ;

Poletto, D ;

Gloghini, A ;

Nanni, P ;

Degan, M ;

Perin, T ;

Ceolin, P ;

Rossi, FM ;

Gattei, V ;

Carbone, A ;

Pinto, A .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (02) :585-596

[6] Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: Involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions [J].

Aldinucci, Donatella ;

Lorenzon, Debora ;

Cattaruzza, Lara ;

Pinto, Antonio ;

Gloghini, Annunziata ;

Carbone, Antonino ;

Colombatti, Alfonso .

INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (04) :769-776

[7] Germinal-center organization and cellular dynamics [J].

Allen, Christopher D. C. ;

Okada, Takaharu ;

Cyster, Jason G. .

IMMUNITY, 2007, 27 (02) :190-202

[8] Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells [J].

Alvaro, T ;

Lejeune, M ;

Salvadó, MT ;

Bosch, R ;

García, JF ;

Jaén, J ;

Banham, AH ;

Roncador, G ;

Montalbán, C ;

Piris, MA .

CLINICAL CANCER RESEARCH, 2005, 11 (04) :1467-1473

[9]

Anagnostopoulos I, 2000, BLOOD, V96, P1889

[10] Specific function of STAT3, SOCS1, and SOCS3 in the regulation of proliferation and survival of classical Hodgkin lymphoma cells [J].

Bans, D ;

Pfitzner, E .

INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (06) :1404-1413

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