Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT3AR expression

被引：88

作者：

Chittajallu, Ramesh ^{[1
]}

Craig, Michael T. ^{[1
]}

McFarland, Ashley ^{[1
]}

Yuan, Xiaoqing ^{[1
]}

Geffen, Scott ^{[1
]}

Tricoire, Ludovic ^{[1
]}

Erkkila, Brian ^{[1
]}

Barron, Sean C. ^{[1
]}

Lopez, Carla M. ^{[1
]}

Liang, Barry J. ^{[1
]}

Jeffries, Brian W. ^{[1
]}

Pelkey, Kenneth A. ^{[1
]}

McBain, Chris J. ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Neurobiol, NIH, Bethesda, MD USA

来源：

NATURE NEUROSCIENCE | 2013年 / 16卷 / 11期

关键词：

OSCILLATIONS IN-VITRO; STRATUM-ORIENS INTERNEURONS; CORTICAL INTERNEURONS; GABAERGIC INTERNEURONS; NETWORK OSCILLATIONS; RAT HIPPOCAMPUS; PERISOMATIC INHIBITION; RECEPTOR ACTIVATION; TRANSGENIC MICE; BASKET CELLS;

D O I：

10.1038/nn.3538

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Forebrain circuits rely upon a relatively small but remarkably diverse population of GABAergic interneurons to bind and entrain large principal cell assemblies for network synchronization and rhythmogenesis. Despite the high degree of heterogeneity across cortical interneurons, members of a given subtype typically exhibit homogeneous developmental origins, neuromodulatory response profiles, morphological characteristics, neurochemical signatures and electrical features. Here we report a surprising divergence among hippocampal oriens-lacunosum moleculare (O-LM) projecting interneurons that have hitherto been considered a homogeneous cell population. Combined immunocytochemical, anatomical and electrophysiological interrogation of Htr3a-GFP and Nkx2-1-cre:RCE mice revealed that O-LM cells parse into a caudal ganglionic eminence-derived subpopulation expressing 5-HT3A receptors (5-HT(3A)Rs) and a medial ganglionic eminence-derived subpopulation lacking 5-HT(3A)Rs. These two cohorts differentially participate in network oscillations, with 5-HT3AR-containing O-LM cell recruitment dictated by serotonergic tone. Thus, members of a seemingly uniform interneuron population can exhibit unique circuit functions and neuromodulatory properties dictated by disparate developmental origins.

引用

页码：1598 / 1607

页数：10

共 51 条

[31] Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic olig2-expressing precursors [J].