THREE NEW C19-DITERPENOID ALKALOIDS FROM ACONITUM APETALUM

被引：6

作者：

Zhang, Jifa ^{[1
]}

Chen, Lin ^{[2
]}

Zhou, Xianli ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China

[2] China West Normal Univ, Sch Chem & Chem Engn, Nanchong 637002, Sichuan, Peoples R China

来源：

HETEROCYCLES | 2018年 / 96卷 / 02期

关键词：

DITERPENOID ALKALOIDS;

D O I：

10.3987/COM-17-13848

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new C-19-diterpenoid alkaloids, named apetaldine H (1), apetaldine I (2) and apetaldine J (3), were isolated from the root of Aconitum apetalum. Their structures were elucidated by extensive spectroscopic analyses including 1D, 2D NMR, and HR-ESI-MS. Compounds (1-3) were evaluated for their cytotoxicity against the MCF-7, HepG2 and H460 human cancer cell lines.

引用

页码：304 / 310

页数：7

共 14 条

[1] A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens [J].

Chen, Lin ;

Shan, Lianhai ;

Xu, Wenliang ;

Zhang, Jifa ;

Huang, Shuai ;

Zhou, Xianli .

NATURAL PRODUCT RESEARCH, 2017, 31 (05) :523-528

[2] Norditerpene and diterpene alkaloids from Aconitum variegatum [J].

Díaz, JG ;

Ruiza, JG ;

Herz, W .

PHYTOCHEMISTRY, 2005, 66 (07) :837-846

[3] Diterpenoid Alkaloids from the Chinese Traditional Herbal "Fuzi" and Their Cytotoxic Activity [J].

Gao, Feng ;

Li, Yuan-Yuan ;

Wang, Dan ;

Huang, Xing ;

Liu, Qian .

MOLECULES, 2012, 17 (05) :5187-5194

[4]

Huang S, 2017, HETEROCYCLES, V94, P485, DOI [10.3987/COM-16-13591, 10.3987/com-16-13591]

[5] A New Diterpenoid Alkaloid from the Roots of a White-Flowering Aconitum orientale Sample [J].

Mericli, Ali H. ;

Cagal-Yurdusever, Nil ;

Ozcelik, Hasan ;

Zapp, Josef ;

Kiemer, Alexandra K. .

HELVETICA CHIMICA ACTA, 2012, 95 (02) :314-319

[6] THE PYRODELPHONINE CHROMOPHORE - CRYSTAL-STRUCTURES OF PYRODELPHININE AND DELPHININE [J].

PELLETIER, SW ;

FINERMOORE, J ;

DESAI, RC ;

MODY, NV ;

DESAI, HK .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (27) :5290-5297

[7]

PELLETIER SW, 1987, HETEROCYCLES, V25, P365

[8]

PELLETIER SW, 1978, TETRAHEDRON LETT, P5045

[9] New C18-diterpenoid alkaloids from Delphinium anthriscifolium var. savatieri [J].

Song, Lei ;

Liang, Xiao-Xia ;

Chen, Dong-Lin ;

Jian, Xi-Xian ;

Wang, Feng-Peng .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (06) :918-921

[10] Diterpenoid alkaloids [J].

Wang, Feng-Peng ;

Chen, Qiao-Hong ;

Liu, Xiao-Yu .

NATURAL PRODUCT REPORTS, 2010, 27 (04) :529-570

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