Towards fabrication of 3D printed medical devices to prevent biofilm formation

被引：142

作者：

Sandler, Niklas ^{[1
]}

Salmela, Ida ^{[1
]}

Fallarero, Adyary ^{[1
]}

Rosling, Ari ^{[2
]}

Khajeheian, Mohammad ^{[2
]}

Kolakovic, Ruzica ^{[1
]}

Genina, Natalja ^{[1
]}

Nyman, Johan ^{[1
]}

Vuorela, Pia ^{[1
]}

机构：

[1] Abo Akad Univ, Dept Biosci, Pharmaceut Sci Lab, FI-20520 Turku, Finland

[2] Abo Akad Univ, Lab Polymer Technol, FI-20500 Turku, Finland

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2014年 / 459卷 / 1-2期

基金：

芬兰科学院;

关键词：

STAPHYLOCOCCUS-AUREUS BIOFILMS; HOT-MELT EXTRUSION; RELEASE;

D O I：

10.1016/j.ijpharm.2013.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The use of three-dimensional (3D) printing technologies is transforming the way that materials are turned into functional devices. We demonstrate in the current study the incorporation of anti-microbial nitrofurantoin in a polymer carrier material and subsequent 3D printing of a model structure, which resulted in an inhibition of biofilm colonization. The approach taken is very promising and can open up new avenues to manufacture functional medical devices in the future. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：62 / 64

页数：3

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