Definition and epidemiology of treatment-resistant depression

被引：639
作者：
Fava, M
Davidson, KG
机构：
[1] Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114
来源：
PSYCHIATRIC CLINICS OF NORTH AMERICA | 1996年 / 19卷 / 02期
关键词：
D O I：
10.1016/S0193-953X(05)70283-5
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Although many depressed patients do improve with adequate antidepressant treatment, a significant proportion fails to reach acceptable levels of functioning and well-being. Currently, however, there is no universally accepted definition of treatment resistance in unipolar depression (TRD). This article proposes an operational definition of TRD and discusses partial response, nonresponse, and methodologic issues that emerge in the assessment of resistance. Finally, possible predictors of failure to respond are reviewed, and an attempt is made to estimate the prevalence of TRD.
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页码：179 / &
页数：23
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