New α-Pyridones with Quorum-Sensing Inhibitory Activity from Diversity-Enhanced Extracts of a Streptomyces sp Derived from Marine Algae

被引：44
|
作者：
Du, Yuqi [1 ]
Sun, Jian [1 ]
Gong, Qianhong [1 ]
Wang, Yi [1 ]
Fu, Peng [1 ]
Zhu, Weiming [1 ,2 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 08期
关键词：
pyridone; QS-inhibition; diversity-enhanced extracts; Streptomyces sp; Enteromorpha prolifera; NATURAL-PRODUCTS; SP OUCMDZ-3434; DERIVATIVES; FUNGUS; AGENTS; POLYSIPHONIA; POLYKETIDES; METABOLITES; UNIT;
D O I：
10.1021/acs.jafc.7b05330
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Four new alpha-pyrones (1-4) and eight known analogues (5-12) were identified from the secondary metabolites of Streptomyces sp. OUCMDZ-3436 derived from the marine green algae Enteromorpha prolifera. Seven new alpha-pyridones (14-20) were constructed by diversity-oriented synthesis, which has been an effective approach to expanding the chemical space of natural-product-like compounds. Compounds 16, 17, 19, and 20 were found to have inhibitory effect on the gene expression controlled by quorum sensing in Pseudomonas aeruginosa QSIS-lasI.
引用
收藏
页码：1807 / 1812
页数：6
相关论文
共 50 条
  • [31] New oxaphenalene derivative from marine-derived Streptomyces griseorubens sp ASMR4
    Hamed, Abdelaaty
    Abdel-Razek, Ahmed S.
    Frese, Marcel
    Wibberg, Daniel
    El-Haddad, Atef F.
    Ibrahim, Tarek M. A.
    Kalinowski, Jorn
    Sewald, Norbert
    Shaaban, Mohamed
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2017, 72 (01): : 53 - 62
  • [32] Nyuzenamides A and B: Bicyclic Peptides with Antifungal and Cytotoxic Activity from a Marine-Derived Streptomyces sp.
    Ul Karim, Md Rokon
    In, Yasuko
    Zhou, Tao
    Harunari, Enjuro
    Oku, Naoya
    Igarashi, Yasuhiro
    ORGANIC LETTERS, 2021, 23 (06) : 2109 - 2113
  • [33] A New Analogue of Echinomycin and a New Cyclic Dipeptide from a Marine-Derived Streptomyces sp LS298
    Zhen, Xin
    Gong, Ting
    Liu, Fu
    Zhang, Pei-Cheng
    Zhou, Wan-Qi
    Li, Yan
    Zhu, Ping
    MARINE DRUGS, 2015, 13 (11): : 6947 - 6961
  • [34] Thermohexins A and B, two new hexacyclicpeptides from marine algae-derived Streptomyces thermolineatus NAK03196
    Zhang, Guo Dong
    Yuan, Cheng Yuan
    Zou, Ling Jiao
    Zhang, Bo
    Jiao, Rui Hua
    TETRAHEDRON LETTERS, 2025, 161
  • [35] Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp. SCS-KFD08
    Fan Dong Kong
    Li Man Zhou
    Qing Yun Ma
    Sheng Zhuo Huang
    Pei Wang
    Hao Fu Dai
    You Xing Zhao
    Archives of Pharmacal Research, 2017, 40 : 25 - 31
  • [36] Tyrosinase Inhibitory Activity of Ethyl Acetate Extracts from Marine Sponge-Derived Fungi Haliclona fascigera
    Handayani, Dian
    Sandrawati, Neny
    Akbar, Sauqi
    Syafni, Nova
    Putra, Deddi Prima
    BIOSCIENCE RESEARCH, 2019, 16 (02): : 2369 - 2373
  • [37] Naseseazines A and B: A New Dimeric Diketopiperazine Framework from a Marine-Derived Actinomycete, Streptomyces sp.
    Raju, Ritesh
    Piggott, Andrew M.
    Conte, Melissa
    Aalbersberg, William G. L.
    Feussner, Klaus
    Capon, Robert J.
    ORGANIC LETTERS, 2009, 11 (17) : 3862 - 3865
  • [38] Albidopyrone, a new α-pyrone-containing metabolite from marine-derived Streptomyces sp NTK 227
    Hohmann, Claudia
    Schneider, Kathrin
    Bruntner, Christina
    Brown, Roselyn
    Jones, Amanda L.
    Goodfellow, Michael
    Kraemer, Marco
    Imhoff, Johannes F.
    Nicholson, Graeme
    Fiedler, Hans-Peter
    Suessmuth, Roderich D.
    JOURNAL OF ANTIBIOTICS, 2009, 62 (02): : 75 - 79
  • [39] The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.
    Mahyudin, Nor Ainy
    Blunt, John W.
    Cole, Anthony L. J.
    Munro, Murray H. G.
    JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012,
  • [40] New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp ZZ745
    Zhang, Di
    Shu, Chenyan
    Lian, Xiaoyuan
    Zhang, Zhizhen
    MARINE DRUGS, 2018, 16 (09):
12345