Comparative toxicity to mice of domoic acid and isodomoic acids A, B and C

被引：27

作者：

Munday, Rex ^{[1
]}

Holland, Patrick T. ^{[2
]}

McNabb, Paul ^{[2
]}

Selwood, Andrew I. ^{[2
]}

Rhodes, Lesley L. ^{[2
]}

机构：

[1] AgResearch, Ruakura Res Ctr, Hamilton, New Zealand

[2] Cawthron Inst, Nelson, New Zealand

来源：

TOXICON | 2008年 / 52卷 / 08期

关键词：

Domoic acid; Isodomoic acids A; B and C; Toxicity in vivo;

D O I：

10.1016/j.toxicon.2008.10.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Seafood in many parts of the world may become contaminated with high levels of domoic acid and domoic acid isomers, and such seafood has been shown to cause toxic effects in humans and in marine animals. Domoic acid itself has been held responsible for the observed effects, although the possible contribution of the isomers to toxicity has not been investigated. In the present study, the acute intraperitoneal toxicity of isodomoic acid C in mice was found to be lower than that of domoic acid. Furthermore, the severities of the behavioural changes induced by isodomoic acids A, B and C were all much lower than that of domoic acid itself, suggesting that these substances pose relatively little risk to human or animal health. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：954 / 956

页数：3

共 44 条

[1] Chemistry of domoic acid, isodomoic acids, and their analogues
Clayden, J
Read, B
Hebditch, KR
TETRAHEDRON, 2005, 61 (24) : 5713 - 5724
[2] Effect of pH on domoic acid toxicity in mice
Nijjar, MS
Madhyastha, MS
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1997, 167 (1-2) : 179 - 185
[3] Effect of pH on domoic acid toxicity in mice
M.S. Nijjar
M.S. Madhyastha
Molecular and Cellular Biochemistry, 1997, 167 : 179 - 185
[4] Isodomoic acids A and C exhibit low KA receptor affinity and reduced in vitro potency relative to domoic acid in region CAI of rat hippocampus
Sawant, P. M.
Weare, B. A.
Holland, P. T.
Selwood, A. I.
King, K. L.
Mikulski, C. M.
Doucette, G. J.
Mountfort, D. O.
Kerr, D. S.
TOXICON, 2007, 50 (05) : 627 - 638
[5] Comparative behavioural toxicity of domoic acid and kainic acid in neonatal rats
Doucette, TA
Strain, SM
Allen, GV
Ryan, CL
Tasker, RAR
NEUROTOXICOLOGY AND TERATOLOGY, 2000, 22 (06) : 863 - 869
[6] A general synthetic approach to the amnesic shellfish toxins: total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F
Lemiere, Gilles
Sedehizadeh, Simon
Toueg, Julie
Fleary-Roberts, Nadia
Clayden, Jonathan
CHEMICAL COMMUNICATIONS, 2011, 47 (13) : 3745 - 3747
[7] PHARMACOLOGY OF SYSTEMICALLY ADMINISTERED DOMOIC ACID IN MICE
TASKER, RA
CONNELL, BJ
STRAIN, SM
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1991, 69 (03) : 378 - 382
[8] Developmental toxicity of domoic acid in zebrafish (Danio rerio)
Tiedeken, JA
Ramsdell, JS
Ramsdell, AF
NEUROTOXICOLOGY AND TERATOLOGY, 2005, 27 (05) : 711 - 717
[9] Toxicity of domoic acid in the marine mussel Mytilus edulis
Dizer, H
Fischer, B
Harabawy, ASA
Hennion, MC
Hansen, PD
AQUATIC TOXICOLOGY, 2001, 55 (3-4) : 149 - 156
[10] MORPHINE DIFFERENTIALLY AFFECTS DOMOIC ACID AND KAINIC ACID TOXICITY INVIVO
TASKER, A
STRAIN, SM
NEUROREPORT, 1992, 3 (09) : 789 - 792

← 1 2 3 4 5 →