Beta Activity in the Subthalamic Nucleus During Sleep in Patients with Parkinson's Disease

被引：51
作者：
Urrestarazu, Elena [1 ,2 ,3 ]
Iriarte, Jorge [1 ,2 ,3 ]
Alegre, Manuel [1 ,2 ,3 ]
Clavero, Pedro [1 ,2 ,3 ]
Rodriguez-Oroz, Mari Cruz [1 ,2 ,3 ]
Guridi, Jorge [1 ,2 ,3 ]
Obeso, Jose A. [1 ,2 ,3 ]
Artieda, Julio [1 ,2 ,3 ]
机构：
[1] CIMA Univ Navarra, Dept Neurol & Neurosurg, Clin Univ, Pamplona, Spain
[2] CIMA Univ Navarra, Sch Med, Pamplona, Spain
[3] CIMA Univ Navarra, Div Neurosci, Pamplona, Spain
来源：
MOVEMENT DISORDERS | 2009年 / 24卷 / 02期
关键词：
Parkinson's disease; motor control; sleep; subthalamic nucleus; local field potentials (LFP); MOVEMENT-RELATED CHANGES; DEEP BRAIN-STIMULATION; HUMAN BASAL GANGLIA; OSCILLATORY ACTIVITY; REM-SLEEP; MODULATION; DOPAMINE; PATHOPHYSIOLOGY; SYNCHRONIZATION; DEPENDENCY;
D O I：
10.1002/mds.22351
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The recordings of local field potentials in the subthalamic nucleus in patients with Parkinson's disease (PD), carried Out through the Stimulators implanted to treat the motor symptoms of the disease, show a prominent basal ("off") activity in the beta range, which is attenuated after dopaminergic therapy. A recent study described improvement of parkinsonian features during rapid eyes movements (REM) sleep. We describe, for the first time, the changes in activity of the subthlamic nucleus (STN) during different sleep stages in Parkinson's disease with special interest in the beta band. Ten patients with PD treated with deep brain stimulation of the STN were studied. Subthalamic local field potentials (LFPs) were recorded through the stimulation electrodes during wakefulness ("off" medication) and different sleep stages. In Stage 2 and slow-wave sleep, a significant decrease of beta activity was recorded. During REM sleep, beta power values were similar to wakefulness values or even higher. These findings indicate that STN activity is modulated and modified during different sleep stages. The increased beta activity during REM sleep is a new but unexpected finding, which requires further analysis. (C) 2008 Movement Disorder Society
引用
收藏
页码：254 / 260
页数：7
相关论文
共 27 条
[1]   Movement-related changes in oscillatory activity in the human subthalamic nucleus:: ipsilateral vs. contralateral movements [J].
Alegre, M ;
Alonso-Frech, F ;
Rodríguez-Oroz, MC ;
Guridi, J ;
Zamarbide, I ;
Valencia, M ;
Manrique, M ;
Obeso, JA ;
Artieda, J .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (09) :2315-2324
[2]   Movement-related changes in cortical oscillatory activity in ballistic, sustained and negative movements [J].
Alegre, M ;
Labarga, A ;
Gurtubay, IG ;
Iriarte, J ;
Malanda, A ;
Artieda, J .
EXPERIMENTAL BRAIN RESEARCH, 2003, 148 (01) :17-25
[3]   Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease [J].
Alonso-Frech, F. ;
Zamarbide, I. ;
Alegre, M. ;
Rodriguez-Oroz, M. C. ;
Guridi, J. ;
Manrique, M. ;
Valencia, M. ;
Artieda, J. ;
Obeso, J. A. .
BRAIN, 2006, 129 :1748-1757
[4]   Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease [J].
Boeve, B. F. ;
Silber, M. H. ;
Saper, C. B. ;
Ferman, T. J. ;
Dickson, D. W. ;
Parisi, J. E. ;
Benarroch, E. E. ;
Ahlskog, J. E. ;
Smith, G. E. ;
Caselli, R. C. ;
Tippman-Peikert, M. ;
Olson, E. J. ;
Lin, S. -C. ;
Young, T. ;
Wszolek, Z. ;
Schenck, C. H. ;
Mahowald, M. W. ;
Castillo, P. R. ;
Del Tredici, K. ;
Braak, H. .
BRAIN, 2007, 130 :2770-2788
[5]   Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease [J].
Brown, P .
MOVEMENT DISORDERS, 2003, 18 (04) :357-363
[6]   Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease [J].
Brown, P ;
Oliviero, A ;
Mazzone, P ;
Insola, A ;
Tonali, P ;
Di Lazzaro, V .
JOURNAL OF NEUROSCIENCE, 2001, 21 (03) :1033-1038
[7]   Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease [J].
Chen, Chiung Chu ;
Litvak, Vladimir ;
Gilbertson, Thomas ;
Kuhn, Andrea ;
Lu, Chin Song ;
Lee, Shih Tseng ;
Tsai, Chon Haw ;
Tisch, Stephen ;
Limousin, Patricia ;
Hariz, Marwan ;
Brown, Peter .
EXPERIMENTAL NEUROLOGY, 2007, 205 (01) :214-221
[8]   Functional mapping of human sensorimotor cortex with electrocorticographic spectral analysis - I. Alpha and beta event-related desynchronization [J].
Crone, NE ;
Miglioretti, DL ;
Gordon, B ;
Sieracki, JM ;
Wilson, MT ;
Uematsu, S ;
Lesser, RP .
BRAIN, 1998, 121 :2271-2299
[9]   Restoration of normal motor control in Parkinson's disease during REM sleep [J].
De Cock, Valerie Cochen ;
Vidailhet, Marie ;
Leu, Smaranda ;
Texeira, Antonio ;
Apartis, Emmanuelle ;
Elbaz, Alexis ;
Roze, Emmanuel ;
Willer, Jean Claude ;
Derenne, Jean Philippe ;
Agid, Yves ;
Arnulf, Isabelle .
BRAIN, 2007, 130 :450-456
[10]   Levodopa-induced modulation of subthalamic beta oscillations during self-paced movements in patients with Parkinson's disease [J].
Doyle, LMF ;
Kühn, AA ;
Hariz, M ;
Kupsch, A ;
Schneider, GH ;
Brown, P .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (05) :1403-1412
123