Facile synthesis of a glycopeptide building block of antifreeze glycoprotein

被引：0
|
作者：
Jiaang, WT [1 ]
Hsiao, KF
Chen, ST
Wang, KT
机构：
[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan
[2] Natl Taiwan Univ, Dept Chem, Taipei 111, Taiwan
来源：
SYNTHESIS-STUTTGART | 1999年 / 09期
关键词：
antifreeze; glycopeptides; solid phase synthesis; tetramethylurea; protecting groups; Moz;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new procedure for synthesizing a building block of antifreeze glycoprotein (AFGP) 1, Moz-Ala-(Gal beta 1--> 3GalNAc alpha 1)Thr-Ala-OH 7 has been developed. The onium salt is an important intermediate to generate alpha-glycopeptide 5 of excellent yield with high selectivity as a key step. One can successfully remove the Moz protective group of glycopeptide selectively with formic acid without cleaving the glycosidic bond.
引用
收藏
页码：1687 / 1690
页数：4
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