A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

被引：702

作者：

Liu, He ^{[1
]}

Wang, Chenyu ^{[1
,2
]}

Li, Chen ^{[1
]}

Qin, Yanguo ^{[1
]}

Wang, Zhonghan ^{[1
]}

Yang, Fan ^{[1
]}

Li, Zuhao ^{[1
]}

Wang, Jincheng ^{[1
]}

机构：

[1] Jilin Univ, Orthopaed Med Ctr, Hosp 2, Changchun 130041, Jilin, Peoples R China

[2] Hallym Univ, 1Hallymdaehak Gil, Chunchon 200702, Gangwon Do, South Korea

来源：

RSC ADVANCES | 2018年 / 8卷 / 14期

基金：

中国国家自然科学基金;

关键词：

IN-VIVO EVALUATION; MESENCHYMAL STEM-CELLS; FIBROBLAST-GROWTH-FACTOR; BONE-MARROW; POLYELECTROLYTE COMPLEX; STAPHYLOCOCCUS-AUREUS; SILVER NANOPARTICLES; POLYVINYL-ALCOHOL; MOLECULAR-WEIGHT; HYALURONIC-ACID;

D O I：

10.1039/c7ra13510f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Functional active wound dressings are expected to provide a moist wound environment, offer protection from secondary infections, remove wound exudate and accelerate tissue regeneration, as well as to improve the efficiency of wound healing. Chitosan-based hydrogels are considered as ideal materials for enhancing wound healing owing to their biodegradable, biocompatible, non-toxic, antimicrobial, biologically adhesive, biological activity and hemostatic effects. Chitosan-based hydrogels have been demonstrated to promote wound healing at different wound healing stages, and also can alleviate the factors against wound healing (such as excessive inflammatory and chronic wound infection). The unique biological properties of a chitosan-based hydrogel enable it to serve as both a wound dressing and as a drug delivery system (DDS) to deliver antibacterial agents, growth factors, stem cells and so on, which could further accelerate wound healing. For various kinds of wounds, chitosan-based hydrogels are able to promote the effectiveness of wound healing by modifying or combining with other polymers, and carrying different types of active substances. In this review, we will take a close look at the application of chitosan-based hydrogels in wound dressings and DDS to enhance wound healing.

引用

页码：7533 / 7549

页数：17

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