A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells

被引：75

作者：

Albers, Aaron E. ^{[1
]}

Dickinson, Bryan C. ^{[1
]}

Miller, Evan W. ^{[1
]}

Chang, Christopher J. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 22期

关键词：

Fluorescent probe; Hydrogen peroxide; Naphthofluorescein; Flow cytometry; Near infrared;

D O I：

10.1016/j.bmcl.2008.08.035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the synthesis, properties, and cellular application of Naphtho-Peroxyfluor-1 (NPF1), a new fluorescent indicator for hydrogen peroxide based on a red-emitting naphthofluorescein platform. Owing to its boronate cages, NPF1 features high selectivity for hydrogen peroxide over a panel of biologically relevant reactive oxygen species (ROS), including superoxide and nitric oxide, as well as excitation and emission profiles in the far-red region of the visible spectrum (>600 nm). Flow cytometry experiments in RAW264.7 macrophages establish that NPF1 can report changes in peroxide levels in living cells. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5948 / 5950

页数：3

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