Rab proteins of Drosophila melanogaster: Novel members of the Rab-protein family

被引：27
|
作者：
Satoh, AK
Tokunaga, F
Ozaki, K
机构：
[1] OSAKA UNIV,GRAD SCH SCI,DEPT BIOL,TOYONAKA,OSAKA 560,JAPAN
[2] OSAKA UNIV,GRAD SCH SCI,DEPT EARTH & SPACE SCI,TOYONAKA,OSAKA 560,JAPAN
来源：
FEBS LETTERS | 1997年 / 404卷 / 01期
基金：
日本学术振兴会;
关键词：
Rab; Ras; vesicle transport; small G-protein; phylogenetic tree; (Drosophila melanogaster);
D O I：
10.1016/S0014-5793(97)00094-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
From a Drosophila head cDNA library, we isolated 9 cDNA clones, each of which encodes a different member of Rab-protein family. Seven of them (DRabs) have more than 80% amino acid identity to the corresponding members of mammalian Rab proteins. The other two proteins (DRabRP3 and 4) show low sequence similarity to any of the known Rab proteins. However, both contain all amino acids conserved in known Rabs. In addition, DRabRP4 has strong GTP-binding activity, when synthesized in E. coli cells. These results indicate that DRabRPs are novel members of the Rab-protein family. Molecular phylogenetic analysis also supported this conclusion. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：65 / 69
页数：5
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