Hydroxycarbonate apatite formation and 5-fluorouracil delivery by strontium containing mesoporous bioactive glass nanoparticles

被引：10

作者：

Tahir, Muhammad Asif ^{[1
]}

Rahman, Muhammad Saif Ur ^{[2
,3
]}

Nisha, Farheen ^{[4
]}

Shahzad, Faisal ^{[5
]}

Jawad, Muhammad Tayyab ^{[6
]}

Bahadur, Ali ^{[7
]}

Qamar, Muhammad Afzal ^{[8
]}

Shoaib, Muhammad ^{[8
]}

机构：

[1] Univ Agr Faisalabad, Dept Chem, Faisalabad, Pakistan

[2] Shenzhen Univ, Inst Adv Study, Shenzhen 518060, Peoples R China

[3] Shenzhen Univ, Coll Phys & Optoelect Engn, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Shenzhen, Peoples R China

[4] Basic Hlth Unit Chak 545 GB Faisalabad, Faisalabad, Pakistan

[5] Govt Coll Univ Faisalabad, Dept Chem, Faisalabad, Pakistan

[6] Univ Lahore, Dept Chem, Lahore, Pakistan

[7] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Transdisciplinary Studies, Seoul 16229, South Korea

[8] Govt Grad Coll Samanabad Faisalabad, Dept Chem, Faisalabad 38000, Pakistan

来源：

CERAMICS INTERNATIONAL | 2022年 / 48卷 / 11期

关键词：

Anti-cancer drug; 5-fluorouracil; Mesoporous bioactive glass; Chemotherapy; Bone regeneration; Sustained release; IN-VITRO; DRUG-RELEASE; BONE REGENERATION; SILICA; SCAFFOLDS; SYSTEM; SR; MG;

D O I：

10.1016/j.ceramint.2022.02.126

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Sol-gel method was employed for the preparation of strontium-doped mesoporous bioactive glass nanoparticles (Sr-MBG NPs). These NPs have the size of 50 +/- 5 nm, a pore size of 8.2 nm, and a surface area of 379 m(2)/g. Biocompatibility was confirmed by MTT and tissue histopathology in Balb/c mice. 5-Fluorouracil (5-Fu) was loaded to obtain Fu-Sr-MBG NPs which posed substantial inhibitory effects on the viability of the cancer cells (AGS). The amount of released drug was controlled by changing the pH of release medium. Formation of hydroxycarbonate apatite (HCA) was evaluated in simulated body fluid (SBF) and confirmed by XRD and FTIR. Thus a multipurpose nano-biomaterial was prepared and screened.

引用

页码：15862 / 15867

页数：6

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