Hydroxycarbonate apatite formation and 5-fluorouracil delivery by strontium containing mesoporous bioactive glass nanoparticles

被引：10

作者：

Tahir, Muhammad Asif ^{[1
]}

Rahman, Muhammad Saif Ur ^{[2
,3
]}

Nisha, Farheen ^{[4
]}

Shahzad, Faisal ^{[5
]}

Jawad, Muhammad Tayyab ^{[6
]}

Bahadur, Ali ^{[7
]}

Qamar, Muhammad Afzal ^{[8
]}

Shoaib, Muhammad ^{[8
]}

机构：

[1] Univ Agr Faisalabad, Dept Chem, Faisalabad, Pakistan

[2] Shenzhen Univ, Inst Adv Study, Shenzhen 518060, Peoples R China

[3] Shenzhen Univ, Coll Phys & Optoelect Engn, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Shenzhen, Peoples R China

[4] Basic Hlth Unit Chak 545 GB Faisalabad, Faisalabad, Pakistan

[5] Govt Coll Univ Faisalabad, Dept Chem, Faisalabad, Pakistan

[6] Univ Lahore, Dept Chem, Lahore, Pakistan

[7] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Transdisciplinary Studies, Seoul 16229, South Korea

[8] Govt Grad Coll Samanabad Faisalabad, Dept Chem, Faisalabad 38000, Pakistan

来源：

CERAMICS INTERNATIONAL | 2022年 / 48卷 / 11期

关键词：

Anti-cancer drug; 5-fluorouracil; Mesoporous bioactive glass; Chemotherapy; Bone regeneration; Sustained release; IN-VITRO; DRUG-RELEASE; BONE REGENERATION; SILICA; SCAFFOLDS; SYSTEM; SR; MG;

D O I：

10.1016/j.ceramint.2022.02.126

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Sol-gel method was employed for the preparation of strontium-doped mesoporous bioactive glass nanoparticles (Sr-MBG NPs). These NPs have the size of 50 +/- 5 nm, a pore size of 8.2 nm, and a surface area of 379 m(2)/g. Biocompatibility was confirmed by MTT and tissue histopathology in Balb/c mice. 5-Fluorouracil (5-Fu) was loaded to obtain Fu-Sr-MBG NPs which posed substantial inhibitory effects on the viability of the cancer cells (AGS). The amount of released drug was controlled by changing the pH of release medium. Formation of hydroxycarbonate apatite (HCA) was evaluated in simulated body fluid (SBF) and confirmed by XRD and FTIR. Thus a multipurpose nano-biomaterial was prepared and screened.

引用

页码：15862 / 15867

页数：6

共 50 条

[21] Beads of acryloylated polyaminoacidic matrices containing 5-fluorouracil for drug delivery
Pitarresi, G
Pierro, P
Giammona, G
Muzzalupo, R
Trombino, S
Picci, N
DRUG DELIVERY, 2002, 9 (02) : 97 - 104
[22] 5-Fluorouracil loaded fibrinogen nanoparticles for cancer drug delivery applications
Rejinold, N. Sanoj
Muthunarayanan, M.
Chennazhi, K. P.
Nair, S. V.
Jayakumar, R.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2011, 48 (01) : 98 - 105
[23] Selenium - containing mesoporous bioactive glass particles: Physicochemical and drug delivery properties
Wang, Xiang
Zhang, Ying
Ma, Yiyi
Chen, Dongya
Yang, Huilin
Li, Mingzhong
CERAMICS INTERNATIONAL, 2016, 42 (02) : 3609 - 3617
[24] Rapid-setting, mesoporous, bioactive glass cements that induce accelerated in vitro apatite formation
Shi, QH
Wang, JF
Zhang, JP
Fan, J
Stucky, GD
ADVANCED MATERIALS, 2006, 18 (08) : 1038 - +
[25] Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications
Nawaz, Qaisar
Rehman, Muhammad Atiq Ur
Burkovski, Andreas
Schmidt, Jochen
Beltran, Ana M.
Shahid, Ameen
Alber, Nina K.
Peukert, Wolfgang
Boccaccini, Aldo R.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2018, 29 (05)
[26] Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications
Qaisar Nawaz
Muhammad Atiq Ur Rehman
Andreas Burkovski
Jochen Schmidt
Ana M. Beltrán
Ameen Shahid
Nina K. Alber
Wolfgang Peukert
Aldo R. Boccaccini
Journal of Materials Science: Materials in Medicine, 2018, 29
[27] Influence of glass composition on the network structure and mineralization of europium containing mesoporous bioactive glass nanoparticles
Yoo, Kyung-Hyeon
Son, Sung-Ae
Park, Jeong-Kil
Yoon, Seog-Young
MATERIALS CHEMISTRY AND PHYSICS, 2024, 317
[28] Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5-fluorouracil
Farjadian, Fatemeh
Moghadam, Maryam
Monfared, Mohammad
Mohammadi-Samani, Soliman
AICHE JOURNAL, 2022, 68 (12)
[29] Study on the role of 5-fluorouracil in the polymerization of butylcyanoacrylate during the formation of nanoparticles
Simeonova, M
Velichkova, R
Ivanova, G
Enchev, V
Abrahams, I
JOURNAL OF DRUG TARGETING, 2004, 12 (01) : 49 - 56
[30] Targeting laryngeal cancer cells with 5-fluorouracil and curcumin using mesoporous silica nanoparticles
Wang, Ding
Yu, Dan
Liu, Xueshibojie
Wang, Qian
Chen, Xuyang
Hu, Xindan
Wang, Qiong
Jin, Chunshun
Wen, Lianji
Zhang, Ling
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2020, 19

← 1 2 3 4 5 →