Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives

被引：33
作者：
Giovannini, Catia [1 ,2 ]
Bolondi, Luigi [1 ,2 ]
Gramantieri, Laura [1 ]
机构：
[1] S Orsola Malpighi Univ Hosp, Ctr Appl Biomed Res CRBA, I-40138 Bologna, Italy
[2] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 01期
关键词：
Notch; p53; hepatocellular carcinoma (HCC); GAMMA-SECRETASE INHIBITOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; TUMOR-SUPPRESSOR FUNCTION; PANCREATIC-CANCER CELLS; HUMAN BREAST-CANCER; DOWN-REGULATION; SIGNALING PATHWAY; STEM-CELLS; RECEPTOR EXPRESSION; LATERAL INHIBITION;
D O I：
10.3390/ijms18010056
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly activated signaling pathways in cancer. This review focuses mainly on the role of Notch3 signaling in hepatocellular carcinoma and its potential therapeutic applications against this malignancy. In this regard, the crosstalk between Notch and p53 may play an important role.
引用
收藏
页数：13
相关论文
共 113 条
  • [11] A role for Numb in p53 stabilization
    Carter, Stephanie
    Vousden, Karen H.
    [J]. GENOME BIOLOGY, 2008, 9 (05)
  • [12] Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
    Chan, Steven M.
    Weng, Andrew P.
    Tibshirani, Robert
    Aster, Jon C.
    Utz, Paul J.
    [J]. BLOOD, 2007, 110 (01) : 278 - 286
  • [13] Suppression of the notch signaling pathway by γ-secretase inhibitor GSI inhibits human nasopharyngeal carcinoma cell proliferation
    Chen, Shi-Ming
    Liu, Jun-Ping
    Zhou, Jun-Xu
    Chen, Chen
    Deng, Yu-Qin
    Wang, Yan
    Tao, Ze-Zhang
    [J]. CANCER LETTERS, 2011, 306 (01) : 76 - 84
  • [14] Chinnaiyan AM, 2010, PROG MOL BIOL TRANSL, V95, P55, DOI 10.1016/B978-0-12-385071-3.00004-6
  • [15] NUMB controls p53 tumour suppressor activity
    Colaluca, Ivan N.
    Tosoni, Daniela
    Nuciforo, Paolo
    Senic-Matuglia, Francesca
    Galimberti, Viviana
    Viale, Giuseppe
    Pece, Salvatore
    Di Fiore, Pier Paolo
    [J]. NATURE, 2008, 451 (7174) : 76 - U11
  • [16] High-level JAG1 mRNA and protein predict poor outcome in breast cancer
    Dickson, Brendan C.
    Mulligan, Anna Marie
    Zhang, Hui
    Lockwood, Gina
    O'Malley, Frances P.
    Egan, Sean E.
    Reedijk, Michael
    [J]. MODERN PATHOLOGY, 2007, 20 (06) : 685 - 693
  • [17] Constitutive Notch2 signaling induces hepatic tumors in mice
    Dill, Michael T.
    Tornillo, Luigi
    Fritzius, Thorsten
    Terracciano, Luigi
    Semela, David
    Bettler, Bernhard
    Heim, Markus H.
    Tchorz, Jan S.
    [J]. HEPATOLOGY, 2013, 57 (04) : 1607 - 1619
  • [18] Notch tumor suppressor function
    Dotto, G. P.
    [J]. ONCOGENE, 2008, 27 (38) : 5115 - 5123
  • [19] Crosstalk of Notch with p53 and p63 in cancer growth control
    Dotto, G. Paolo
    [J]. NATURE REVIEWS CANCER, 2009, 9 (08) : 587 - 595
  • [20] CELLULAR IMMORTALITY - A LATE EVENT IN THE PROGRESSION OF HUMAN SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK ASSOCIATED WITH P53 ALTERATION AND A HIGH-FREQUENCY OF ALLELE LOSS
    EDINGTON, KG
    LOUGHRAN, OP
    BERRY, IJ
    PARKINSON, EK
    [J]. MOLECULAR CARCINOGENESIS, 1995, 13 (04) : 254 - 265
12345678910