Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives

被引：33
作者：
Giovannini, Catia [1 ,2 ]
Bolondi, Luigi [1 ,2 ]
Gramantieri, Laura [1 ]
机构：
[1] S Orsola Malpighi Univ Hosp, Ctr Appl Biomed Res CRBA, I-40138 Bologna, Italy
[2] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 01期
关键词：
Notch; p53; hepatocellular carcinoma (HCC); GAMMA-SECRETASE INHIBITOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; TUMOR-SUPPRESSOR FUNCTION; PANCREATIC-CANCER CELLS; HUMAN BREAST-CANCER; DOWN-REGULATION; SIGNALING PATHWAY; STEM-CELLS; RECEPTOR EXPRESSION; LATERAL INHIBITION;
D O I：
10.3390/ijms18010056
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly activated signaling pathways in cancer. This review focuses mainly on the role of Notch3 signaling in hepatocellular carcinoma and its potential therapeutic applications against this malignancy. In this regard, the crosstalk between Notch and p53 may play an important role.
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页数：13
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