Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management

被引：115

作者：

Peterson, Julie A. ^{[1
]}

McFarland, Janice G. ^{[2
]}

Curtis, Brian R. ^{[2
]}

Aster, Richard H. ^{[1
,3
]}

机构：

[1] Med Coll Wisconsin, Blood Res Inst, BloodCtr Wisconsin, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Platelet & Neutrophil Immunol Lab, BloodCtr Wisconsin, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2013年 / 161卷 / 01期

关键词：

neonatal thrombocytopenia; platelet antigens; alloimmune thrombocytopenia; PLATELET-SPECIFIC ALLOANTIGEN; AMINO-ACID POLYMORPHISM; MEMBRANE GLYCOPROTEIN-IIIA; SINGLE-POINT MUTATION; RGD BINDING DOMAIN; HLA-B LOCUS; BETA(3) INTEGRIN; FETOMATERNAL ALLOIMMUNIZATION; ANTIGEN-EXPRESSION; FETAL;

D O I：

10.1111/bjh.12235

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.

引用

页码：3 / 14

页数：12

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