Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management

被引：115
作者：
Peterson, Julie A. [1 ]
McFarland, Janice G. [2 ]
Curtis, Brian R. [2 ]
Aster, Richard H. [1 ,3 ]
机构：
[1] Med Coll Wisconsin, Blood Res Inst, BloodCtr Wisconsin, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Platelet & Neutrophil Immunol Lab, BloodCtr Wisconsin, Milwaukee, WI 53226 USA
[3] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2013年 / 161卷 / 01期
关键词：
neonatal thrombocytopenia; platelet antigens; alloimmune thrombocytopenia; PLATELET-SPECIFIC ALLOANTIGEN; AMINO-ACID POLYMORPHISM; MEMBRANE GLYCOPROTEIN-IIIA; SINGLE-POINT MUTATION; RGD BINDING DOMAIN; HLA-B LOCUS; BETA(3) INTEGRIN; FETOMATERNAL ALLOIMMUNIZATION; ANTIGEN-EXPRESSION; FETAL;
D O I：
10.1111/bjh.12235
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.
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页码：3 / 14
页数：12
相关论文
共 118 条
[1]   The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes [J].
Ahlen, Maria Therese ;
Husebekk, Anne ;
Killie, Mette Kjaer ;
Kjeldsen-Kragh, Jens ;
Olsson, Martin L. ;
Skogen, Bjorn .
CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2012,
[2]   Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia [J].
Arinsburg, Suzanne A. ;
Shaz, Beth H. ;
Westhoff, Connie ;
Cushing, Melissa M. .
AMERICAN JOURNAL OF HEMATOLOGY, 2012, 87 (05) :525-528
[3]   Diagnosis and Management of Neonatal Alloimmune Thrombocytopenia [J].
Arnold, Donald M. ;
Smith, James W. ;
Kelton, John G. .
TRANSFUSION MEDICINE REVIEWS, 2008, 22 (04) :255-267
[4]  
Aster R H, 2007, Immunohematology, V23, P2
[5]   Low-avidity anti-HPA-1a alloantibodies are capable of antigen-positive platelet destruction in the NOD/SCID mouse model of alloimmune thrombocytopenia [J].
Bakchoul, Tamam ;
Kubiak, Sebastian ;
Krautwurst, Annika ;
Roderfeld, Monika ;
Siebert, Hans C. ;
Bein, Gregor ;
Sachs, Ulrich J. ;
Santoso, Sentot .
TRANSFUSION, 2011, 51 (11) :2455-2461
[6]   Antepartum treatment without early cordocentesis for standard-risk alloimmune thrombocytopenia - A randomized controlled trial [J].
Berkowitz, Richard L. ;
Lesser, Martin L. ;
McFarland, Janice G. ;
Wissert, Megan ;
Primiani, Andrea ;
Hung, Crystal ;
Bussel, James B. .
OBSTETRICS AND GYNECOLOGY, 2007, 110 (02) :249-255
[7]   Parallel randomized trials of risk-based therapy for fetal alloimmune thrombocytopenia [J].
Berkowitz, RL ;
Kolb, EA ;
McFarland, JG ;
Wissert, M ;
Primani, A ;
Lesser, M ;
Bussel, JB .
OBSTETRICS AND GYNECOLOGY, 2006, 107 (01) :91-96
[8]   The new platelet alloantigen Caba: a single point mutation Gln716His on the α2 integrin [J].
Bertrand, Gerald ;
Jallu, Vincent ;
Saillant, Dominique ;
Kervran, Dominique ;
Martageix, Corinne ;
Kaplan, Cecile .
TRANSFUSION, 2009, 49 (10) :2076-2083
[9]   The relationship of anti-HPA-1a amount to severity of neonatal alloimmune thrombocytopenia - Where does it stand? [J].
Bessos, Hagop ;
Killie, Mette Kjaer ;
Seghatchian, Jerard ;
Skogen, Bjorn ;
Urbaniak, Stanislaw J. .
TRANSFUSION AND APHERESIS SCIENCE, 2009, 40 (02) :75-78
[10]   ALLOIMMUNIZATION TO THE PLA1 PLATELET ANTIGEN - RESULTS OF A PROSPECTIVE-STUDY [J].
BLANCHETTE, VS ;
CHEN, L ;
DEFRIEDBERG, ZS ;
HOGAN, VA ;
TRUDEL, E ;
DECARY, F .
BRITISH JOURNAL OF HAEMATOLOGY, 1990, 74 (02) :209-215
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