Effect of PVP K30 and/or l-Arginine on Stability Constant of Etoricoxib-HPCD Inclusion Complex: Preparation and Characterization of Etoricoxib-HPCD Binary System

被引：8

作者：

Shah, Manali ^{[1
]}

Karekar, Poonam ^{[1
]}

Sancheti, Pankajkumar ^{[1
]}

Vyas, Vikrant ^{[1
]}

Pore, Yogesh ^{[1
]}

机构：

[1] Govt Coll Pharm, Dept Pharmaceut Chem, Karad 415124, Maharashtra, India

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2009年 / 35卷 / 01期

关键词：

etoricoxib; HPCD; stability constant; phase solubility; 1HNMR; dissolution rate; HYDROXYPROPYL-BETA-CYCLODEXTRIN; WATER-SOLUBLE POLYMERS; SELECTIVE CYCLOOXYGENASE-2 INHIBITOR; SOLID-STATE CHARACTERIZATION; NUCLEAR-MAGNETIC-RESONANCE; PHYSICOCHEMICAL CHARACTERIZATION; DISSOLUTION CHARACTERISTICS; MULTICOMPONENT SYSTEMS; NAPROXEN; SOLUBILITY;

D O I：

10.1080/03639040802220292

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of polyvinyl pyrrolidone (PVP) K30 and/or l-arginine on etoricoxib-HPCD complex was investigated. The phase solubility profiles were classified as AL-type, both in absence or presence of auxiliary substances used. The apparent stability constant (Kc) of binary complex obtained at room temperature, 371.80 2.61 M-1, was decreased with the addition of PVP and arginine indicating no benefit of addition of auxiliary substances to promote higher complexation efficiency. Therefore, solid etoricoxib-HPCD binary systems were prepared and characterized by proton nuclear magnetic resonance spectroscopy (1HNMR), X-ray powder diffractometry, Fourier transformation-infrared spectroscopy, and dissolution studies. Among all binary systems, a lyophilized product showed superior performance in enhancing dissolution of etoricoxib.

引用

页码：118 / 129

页数：12