C-telopeptide pyridinoline cross-links - Sensitive indicators of periodontal tissue destruction

被引：37

作者：

Giannobile, WV ^{[1
]}

机构：

[1] Univ Michigan, Dept Periodont Prevent Geriatr, Ann Arbor, MI 48109 USA

来源：

INHIBITION OF MATRIX METALLOPROTEINASES: THERAPEUTIC APPLICATIONS | 1999年 / 878卷

关键词：

D O I：

10.1111/j.1749-6632.1999.tb07698.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption In osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants, Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.

引用

页码：404 / 412

页数：9

共 24 条

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