Copper-Catalyzed Aerobic C(sp2)-H Functionalization for C-N Bond Formation: Synthesis of Pyrazoles and Indazoles

被引：231

作者：

Li, Xianwei ^{[1
]}

He, Li ^{[1
]}

Chen, Huoji ^{[1
]}

Wu, Wanqing ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou S10640, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 08期

基金：

中国国家自然科学基金;

关键词：

EFFICIENT SYNTHESIS; H BONDS; OXIDATIVE CYCLIZATION; INTERNAL ALKYNES; TERMINAL ALKYNES; PALLADIUM; AMINATION; AMIDATION; OXYGEN; REARRANGEMENT;

D O I：

10.1021/jo400162d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, practical, and highly efficient synthesis of pyrazoles and indazoles via copper-catalyzed direct aerobic oxidative C(sp(2))-H amination has been reported herein. This process tolerated a variety of functional groups under mild conditions. Further diversification of pyrazoles was also investigated, which provided its potential for drug discovery.

引用

页码：3636 / 3646

页数：11

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