Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting

被引：80
作者：
Yang, Yong [1 ]
Jiang, Ji-Sen [1 ]
Du, Bing [2 ]
Gan, Zhi-Feng [1 ]
Qian, Min [2 ]
Zhang, Ping [2 ]
机构：
[1] E China Normal Univ, Dept Phys, Ctr Funct Nanomat & Devices, Shanghai 200062, Peoples R China
[2] E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2009年 / 20卷 / 01期
关键词：
IRON-OXIDE NANOPARTICLES; IN-VIVO; PHAGE DISPLAY; PEPTIDE; TUMORS; PH; MICROSPHERES; ADRIAMYCIN; FERRITES; RELEASE;
D O I：
10.1007/s10856-008-3577-0
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
By loading doxorubicin (DOX) on 5-carboxyl-fluorescein (FAM) labeled AGKGTPSLETTP peptide (A54) coupled starch-coated iron oxide nanoparticles (SIONs), we prepared a novel aqueous drug delivery system with both magnetic and biomolecular targeting, which was specific to human hepatocellular carcinoma cell line BEL-7402. The saturated extent of adsorption reached 2.0 mg DOX/mg A54-SIONs at 28A degrees C, which provided a rather high dose of DOX loading for application. Tests in vitro demonstrated the specificity of DOX-loaded A54-SIONs to BEL-7402 cells. The microscopy images proved that DOX-loaded A54-SIONs were successfully targeted to tumor tissue of nude mice with an external magnetic field in vivo. MTT assay showed higher cytostatic effect of DOX-loaded A54-SIONs to hepatocellular carcinoma cells BEL-7402 than that of DOX-loaded SIONs.
引用
收藏
页码：301 / 307
页数：7
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