Stiff man syndrome and variants

被引：0

作者：

Meinck, H-M ^{[1
]}

机构：

[1] Neurol Univ Klin Heidelberg, D-69120 Heidelberg, Germany

来源：

NERVENARZT | 2013年 / 84卷 / 04期

关键词：

Stiff man syndrome; Stiff person syndrome; GAD autoantibodies; GlyR autoantibodies; Paraneoplastic disorder; PERSON SYNDROME; INTRATHECAL BACLOFEN; RIGIDITY; AUTOIMMUNITY; ANTIBODIES; MYOCLONUS;

D O I：

10.1007/s00115-012-3604-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stiff man syndrome (SMS) and its variants are rare neurological disorders with unusual, often awkward motor and psychological symptoms. Misdiagnoses are frequent and differentiation from psychogenic movement disorder may be difficult. Clinical suspicion can be substantiated by neurophysiological and immunological testing. Autoimmunity against certain proteins of inhibitory synapses appears to be a key feature that links SMS to other autoimmune encephalopathies and endocrinopathies. According to retrospective analyses a front-loaded long-term methylprednisolone treatment appears to be most effective.

引用

页码：450 / 454

页数：5

共 19 条

[1] A critical update on the immunopathogenesis of Stiff Person Syndrome
Alexopoulos, Harry
Dalakas, Marinos C.
[J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2010, 40 (11) : 1018 - 1025
[2] Intrathecal baclofen for stiff-person syndrome: Life-threatening intermittent catheter leakage
Bardutzky, J
Tronnier, V
Schwab, S
Meinck, HM
[J]. NEUROLOGY, 2003, 60 (12) : 1976 - 1978
[3] Head retraction reflex in stiff-man syndrome and related disorders
Berger, C
Meinck, HM
[J]. MOVEMENT DISORDERS, 2003, 18 (08) : 906 - 911
[4] Autoimmunity to gephyrin in Stiff-Man syndrome
Butler, MH
Hayashi, A
Ohkoshi, N
Villmann, C
Becker, CM
Feng, GP
De Camilli, P
Solimena, M
[J]. NEURON, 2000, 26 (02) : 307 - 312
[5] High-dose intravenous immune globulin for stiff-person syndrome
Dalakas, MC
Fujii, M
Li, M
Lutfi, B
Kyhos, J
McElroy, B
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (26) : 1870 - 1876
[6] Diener HC, 2012, LEITLINIEN DIAGNOSTI, V5th fully reviced
[7] Stiff-man syndrome:: identification of 17β-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen
Dinkel, K
Rickert, M
Möller, G
Adamski, J
Meinck, HM
Richter, W
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2002, 130 (1-2) : 184 - 193
[8] Hansen N, 2012, EXP NEUROL, V22, DOI [10.1016/j.expneu-rol.2012.10.013, DOI 10.1016/J.EXPNEU-R0L.2012.10.013]
[9] Specific phobia is a frequent non-motor feature in stiff man syndrome
Henningsen, P
Meinck, HM
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2003, 74 (04) : 462 - 465
[10] Progressive encephalomyelitis, rigidity, and myoclonus: A novel glycine receptor antibody
Hutchinson, M.
Waters, P.
McHugh, J.
Gorman, G.
O'Riordan, S.
Connolly, S.
Hager, H.
Yu, P.
Becker, C. -M.
Vincent, A.
[J]. NEUROLOGY, 2008, 71 (16) : 1291 - 1292

← 1 2 →