Viral Manipulations of the Cullin-RING Ubiquitin Ligases

被引：16

作者：

Liu, Ying ^{[1
]}

Tan, Xu ^{[1
]}

机构：

[1] Tsinghua Univ, Beijing Frontier Res Ctr Biol Struct, Beijing Adv Innovat Ctr Struct Biol,Sch Pharmaceu, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing, Peoples R China

来源：

CULLIN-RING LIGASES AND PROTEIN NEDDYLATION: BIOLOGY AND THERAPEUTICS | 2020年 / 1217卷

基金：

中国国家自然科学基金;

关键词：

Cullins; Virus infection; CRL; Degradation; Ubiquitination; IMMUNODEFICIENCY-VIRUS TYPE-1; SMALL-MOLECULE INHIBITION; F-BOX PROTEINS; CBF-BETA; HIV-1; INFECTION; INNATE IMMUNITY; HUMAN APOBEC3G; CELL-SURFACE; VIF; COMPLEX;

D O I：

10.1007/978-981-15-1025-0_7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cullin-RING ubiquitin ligases (CRLs) are efficient and diverse toolsets of the cells to regulate almost every biological process. However, these characteristics have also been usurped by many viruses to optimize for their replication. CRLs are often at the forefront of the arms races in the coevolution of viruses and hosts. Here we review the modes of actions and functional consequences of viral manipulations of host cell CRLs. We also discuss the therapeutic applications to target these viral manipulations for treating viral infections.

引用

页码：99 / 110

页数：12

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