Enantiocomplementary access to carba-analogs of C-nucleoside derivatives by recombinant Baeyer-Villiger monooxygenases

被引：13

作者：

Bianchi, Dario A. ^{[2
,3
]}

Moran-Ramallal, Roberto ^{[1
]}

Iqbal, Naseem ^{[1
]}

Rudroff, Florian ^{[1
]}

Mihovilovic, Marko D. ^{[1
]}

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] Univ Nacl Rosario, Inst Quim Rosario IQUIR, CONICET UNR, RA-2000 Rosario, Santa Fe, Argentina

[3] Univ Nacl Rosario, Fac Ciencias Bioquim Farmaceut, RA-2000 Rosario, Santa Fe, Argentina

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 09期

基金：

奥地利科学基金会;

关键词：

Baeyer-Villiger monooxygenase; C-Nucleoside; Carba-showdomycin; Carba-C-nucleoside; CYCLOHEXANONE MONOOXYGENASE; XANTHOBACTER; SHOWDOMYCIN; BIOCATALYST; COMAMONAS; CLONING;

D O I：

10.1016/j.bmcl.2013.02.085

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel and stereoselective synthetic route towards carba-C-nucleosides was investigated applying an enantiodivergent biooxidation strategy by two different Baeyer-Villiger monooxygenases. Within only three chemo-enzymatic steps it was possible to introduce four chiral centers starting from commercially available non-chiral starting material. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2718 / 2720

页数：3

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