COVID-19 and the endothelium

被引：71

作者：

Jung, F. ^{[1
]}

Krueger-Genge, A. ^{[2
]}

Franke, R. P. ^{[3
]}

Hufert, F. ^{[4
,5
]}

Kuepper, J. -H. ^{[1
,5
]}

机构：

[1] Brandenburg Univ Technol Cottbus Senftenberg, Mol Cell Biol, Inst Biotechnol, Cottbus, Germany

[2] Fraunhofer Inst Appl Polymer Res IAP, Div Life Sci & Bioproc, Dept Healthcare Biomat & Cosmeceut, Potsdam, Germany

[3] Univ Ulm, Dept Biomat, Ulm, Germany

[4] Brandenburg Med Sch Fontane, Inst Microbiol & Virol, Senftenberg, Germany

[5] Brandenburg Med Sch Fontane & Univ Potsdam, Joint Fac Brandenburg Univ Technol Cottbus Senfte, Fac Hlth Sci, Potsdam, Germany

来源：

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 2020年 / 75卷 / 01期

关键词：

COVID-19; endocytosis; endothelial cell dysfunction; endotheliitis; PULMONARY-EMBOLISM; ACE2; SARS-COV-2; RECEPTOR; CORONAVIRUS; EXPRESSION; CELLS;

D O I：

10.3233/CH-209007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is growing evidence that COVID-19 not only affects the lungs but beyond that the endothelial system. Recent studies showed that this can lead to microcirculatory impairments and in consequence to functional disorders of all inner organs. The combination of endothelial dysfunction with a generalized inflammatory state and complement elements may together contribute to the overall pro-coagulative state described in COVID-19 patients leading to venular as well as to arteriolar occlusions.

引用

页码：7 / 11

页数：5

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