Doped TiO2 anodic layers of enhanced antibacterial properties

被引：51

作者：

Arenas, M. A. ^{[1
]}

Perez-Jorge, C. ^{[1
]}

Conde, A. ^{[1
]}

Matykina, E. ^{[1
]}

Hernandez-Lopez, J. M. ^{[1
]}

Perez-Tanoira, R. ^{[1
]}

de Damborenea, J. J. ^{[1
]}

Gomez-Barrena, E. ^{[1
]}

Esteba, J. ^{[1
]}

机构：

[1] CSIC, Ctr Nacl Invest Met CENIM, Madrid, Spain

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 105卷

关键词：

BACTERIAL ADHERENCE; BIOFILM DEVELOPMENT; TITANIUM; ADHESION; NANOTUBES;

D O I：

10.1016/j.colsurfb.2012.12.051

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Ti-6Al-4V joint replacement implants foster uncemented fixation in orthopaedic surgery. However, bacterial colonization competes with host cells and ultimately may produce implant-related difficult-to-treat infections, justifying the efforts to obtain infection-resistant materials. In a previous work, the authors demonstrated the antibacterial properties of anodic fluoride-TiO2 nanostructured layers on Ti-6Al-4V alloy. In this work, the anodizing bath has been modified in order to grow fluoride-TiO2 barrier layers (FBL). A bacterial adherence protocol, run with reference and six different clinical strains of Staphylococcus aureus and Staphylococcus epidermidis, showed a statistically significant decrease in the percentage of covered surface (p<0.0001, Kruskal-Wallis test) for FBL specimens when compared with non fluoride-containing specimens, i.e. chemically polished Ti-6Al-4V and F-free TiO2 barrier layers. The results obtained on the F-barrier layers allowed discrimination between the effects of the presence of fluoride in the layer and the layer nanostructure on bacterial adhesion. © 2013 Elsevier B.V.

引用

页码：106 / 112

页数：7

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