Solution thermodynamics of pyrazinamide, isoniazid, and p-aminobenzoic acid in buffers and octanol

被引：13

作者：

Blokhina, Svetlana V. ^{[1
]}

Ol'khovich, Marina V. ^{[1
]}

Sharapova, Angelica V. ^{[1
]}

Volkova, Tatyana V. ^{[1
]}

Perlovich, German L. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Solut Chem, Ivanovo 153045, Russia

来源：

JOURNAL OF CHEMICAL THERMODYNAMICS | 2015年 / 91卷

基金：

俄罗斯科学基金会;

关键词：

Biologically active compounds; Solubility; Thermophysical parameters; Solvation; ANTITUBERCULOSIS DRUGS; BENZOIC-ACID; DERIVATIVES; SOLUBILITY; SOLVATION;

D O I：

10.1016/j.jct.2015.08.022

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The solubility values of pyrazinamide, isoniazid, and p-aminobenzoic acid in buffers (pH 2.0 and 7.4) and octanol were measured in the temperature range of 293.15 to 313.15 K. The dissolution Gibbs energy, enthalpy, and entropy were calculated. The dissolving process was endothermic and enthalpy-determined. The activity coefficients of the compounds at infinite dilution were determined based on the solubility data and thermophysical parameters. A positive deviation from the ideality was observed in all the solutions. A common tendency of the solubility increase with a decrease in the activity coefficients at T = 298.15 K was revealed for the investigated solute-solvent systems. The excess thermodynamic solubility functions were calculated from the temperature dependences of the activity coefficients. The solvation processes were found to have a considerable influence on the solubility of the substances in solutions studied. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：396 / 403

页数：8

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