Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility

被引：29
|
作者：
Van Baelen, Kurt [1 ]
Van Eygen, Veerle [1 ]
Rondelez, Evelien [1 ]
Stuyver, Lieven J. [1 ]
机构：
[1] Virco BVBA, B-2800 Mechelen, Belgium
来源：
AIDS | 2008年 / 22卷 / 14期
关键词：
D O I：
10.1097/QAD.0b013e32830f9703
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The contribution of clade-specific polymorphisms in the HIV-1 integrase gene towards integrase inhibitor phenotypic susceptibility was tested on 137 clinical isolates, of which 60 were non-clade B strains. Control Q148R mutant virus showed fold change values of 17.85 +/- 2.77 and 88.94 +/- 9.02 for raltegravir and elvitegravir, respectively, whereas the average fold change for the clinical samples was 0.91 +/- 0.40, and 0.84 +/- 0.37. Phenotypic testing proved that clade-specific integrase polymorphisms do not contribute to reduced susceptibility towards integrase inhibitors.
引用
收藏
页码：1877 / 1880
页数：4
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