Protective immunity to Shiga-like toxin I following oral immunization with Shiga-like toxin I B-subunit-producing Vibrio cholerae CVD 103-HgR

被引：51

作者：

Acheson, DWK ^{[1
]}

Levine, MM ^{[1
]}

Kaper, JB ^{[1
]}

Keusch, GT ^{[1
]}

机构：

[1] UNIV MARYLAND, CTR VACCINE DEV, BALTIMORE, MD 21201 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 01期

关键词：

D O I：

10.1128/IAI.64.1.355-357.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study addresses a mechanism for inducing systemic immunity to Shiga-like toxins by oral administration of a Shiga-like toxin I B-subunit-expressing Vibrio cholerae vaccine strain [CVD 103-HgR(pDA60)]. Two sets of three rabbits were given either CVD 103-HgR or CVD 103-HgR(pDA60) orally. All rabbits immunized with CVD 103-HgR(pDA60) developed neutralizing serum antibodies to Shiga like toxin I. None of the controls developed such antibodies.

引用

页码：355 / 357

页数：3

共 23 条

[1] COMPARISON OF SHIGA-LIKE TOXIN-I B-SUBUNIT EXPRESSION AND LOCALIZATION IN ESCHERICHIA-COLI AND VIBRIO-CHOLERAE BY USING TRC OR IRON-REGULATED PROMOTER SYSTEMS [J].

ACHESON, DWK ;

CALDERWOOD, SB ;

BOYKO, SA ;

LINCICOME, LL ;

KANE, AV ;

DONOHUEROLFE, A ;

KEUSCH, GT .

INFECTION AND IMMUNITY, 1993, 61 (03) :1098-1104

[2]

ACHESON DWK, 1994, INT CONGR SER, V1072, P109

[3]

ACHESON DWK, 1995, UNPUB

[4]

ACHESON DWK, 1995, INFECT IMMUN, V63, P601

[5] SITE OF ACTION OF A VERO TOXIN (VT2) FROM ESCHERICHIA-COLI O157-H7 AND OF SHIGA TOXIN ON EUKARYOTIC RIBOSOMES - RNA N-GLYCOSIDASE ACTIVITY OF THE TOXINS [J].

ENDO, Y ;

TSURUGI, K ;

YUTSUDO, T ;

TAKEDA, Y ;

OGASAWARA, T ;

IGARASHI, K .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 171 (1-2) :45-50

[6] QUANTITATIVE MICROTITER CYTO-TOXICITY ASSAY FOR SHIGELLA TOXIN [J].

GENTRY, MK ;

DALRYMPLE, JM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1980, 12 (03) :361-366

[7] AN ENZYMATIC MUTANT OF SHIGA-LIKE TOXIN-II VARIANT IS A VACCINE CANDIDATE FOR EDEMA DISEASE OF SWINE [J].

GORDON, VM ;

WHIPP, SC ;

MOON, HW ;

OBRIEN, AD ;

SAMUEL, JE .

INFECTION AND IMMUNITY, 1992, 60 (02) :485-490

[8] SHIGA-LIKE TOXINS IN HEMOLYTIC-UREMIC SYNDROME AND THROMBOTIC THROMBOCYTOPENIC PURPURA [J].

HOFMANN, SL .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1993, 306 (06) :398-406

[9] PATHOGENESIS OF SHIGELLA DIARRHEA .11. ISOLATION OF A SHIGELLA TOXIN-BINDING GLYCOLIPID FROM RABBIT JEJUNUM AND HELA-CELLS AND ITS IDENTIFICATION AS GLOBOTRIAOSYLCERAMIDE [J].

JACEWICZ, M ;

CLAUSEN, H ;

NUDELMAN, E ;

DONOHUEROLFE, A ;

KEUSCH, GT .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 163 (06) :1391-1404

[10]

JACKSON MP, 1987, FEMS MICROBIOL LETT, V44, P109, DOI 10.1111/j.1574-6968.1987.tb02252.x

← 1 2 3 →