Mathematical modeling of hepatitis B virus infection for antiviral therapy using LHAM

被引：4

作者：

Aniji, M. ^{[1
]}

Kavitha, N. ^{[2
]}

Balamuralitharan, S. ^{[3
]}

机构：

[1] Univ Coll Engn, Pattukkottai 614701, Tamil Nadu, India

[2] Univ Coll Engn, Dept Math, Pattukkottai 614701, Tamil Nadu, India

[3] SRM Inst Sci & Technol, Fac Engn & Technol, Dept Math, Kattankulathur 603203, Tamil Nadu, India

来源：

ADVANCES IN DIFFERENCE EQUATIONS | 2020年 / 2020卷 / 01期

关键词：

HBV; Antiviral therapy; LHAM; CTL; Immune; Mathematical modeling; 34G20; 34A34; HBV; TRANSMISSION; DYNAMICS; EPIDEMIOLOGY; VACCINATION; PREVALENCE;

D O I：

10.1186/s13662-020-02770-2

中图分类号：

O29 [应用数学];

学科分类号：

070104 ;

摘要：

Anti-viral therapy is comparatively very effective for patients who get affected by the hepatitis B virus. It is of prime importance to understand the different relations among the viruses, immune responses and overall health of the liver. In this paper, mathematical modeling is done to analyze and understand the effect of antiviral therapy using LHAM which describes the possible relation to HBV and target liver cells. The numerical simulations and error analysis are done up to a sixth-order approximation with the help of Matlab. This paper analyzes how the number of infected cells largely gets reduced and also how the liver damage can be controlled. Therefore, the treatment is successful for HBV infected patients.

引用

页数：19