Chemical and biological evaluation of some new antipyrine derivatives with particular properties

被引：19

作者：

Remes, C. ^{[1
]}

Paun, A. ^{[1
]}

Zarafu, I. ^{[1
]}

Tudose, M. ^{[2
]}

Caproiu, M. T. ^{[3
]}

Ionita, G. ^{[2
]}

Bleotu, C. ^{[4
]}

Matei, L. ^{[4
]}

Ionita, P. ^{[1
]}

机构：

[1] Univ Bucharest, Dept Chem Biochem & Catalysis, Bucharest 050663, Romania

[2] Inst Phys Chem, Bucharest 060021, Romania

[3] Inst Organ Chem, Bucharest 060023, Romania

[4] Inst Virol, Bucharest 030304, Romania

来源：

BIOORGANIC CHEMISTRY | 2012年 / 41-42卷

关键词：

Antipyrine; Crown ether; NBD; Nitroxide; Isoniazid; Synthesis; SCAVENGING ACTIVITY; OXIDATIVE STRESS; QSAR; AMINOPYRINE;

D O I：

10.1016/j.bioorg.2011.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Starting from 4-amino-antipyrine, six new compounds were synthesized and characterized. The new compounds contain moieties with particular properties, such are ionophore (benzo-15-crown-5), fluorescent (nitrobenzofurazan), stable free radical (nitroxide), or other types of biological active residues, like nitroderivatives, antipyrine or isoniazid residues. They were fully characterized by appropriate means (H-1 and (CNMR)-C-13, IR, UV-Vis, fluorescence, EPR, elemental analysis) and some of their biological properties were evaluated. Hydrophobicity (R-MO, log P), total antioxidant capacity (TAC), and antimicrobial properties are also presented and discussed. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：6 / 12

页数：7

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