Fungal and mycobacterial infections after Campath (alemtuzumab) induction for renal transplantation

被引：19

作者：

Walsh, R. ^{[1
]}

Ortiz, J. ^{[1
]}

Foster, P. ^{[1
]}

Palma-Vargas, J. ^{[1
]}

Rosenblatt, S. ^{[1
]}

Wright, F. ^{[1
]}

机构：

[1] Texas Transplant Inst, San Antonio, TX 78229 USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2008年 / 10卷 / 04期

关键词：

renal transplant; infection; Mycobacterium tuberculosis; candidiasis; alemtuzumab;

D O I：

10.1111/j.1399-3062.2007.00292.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objectives: To report our experience with fungal and mycobacterial (tuberculosis) infection following induction with Campath (alemtuzumab). Methods:We reviewed the database of 477 renal transplant patients induced with alemtuzumab. All those who had a fungal or mycobacterial infection were found, and the details of these complications reviewed. Results: Five patients were found to have fungal (3) or tuberculous (2) infection. The incidence of fungal infection was 0.6% and that of tuberculous infection was 0.4%. Mortality rates for these 2 types of infection were 50% and 100%, respectively. During the same period, there was an overall mortality of 1.7% (n = 5). No surviving patient lost graft function. Conclusion: Although fungal and mycobacterial infections caused significant mortality, the overall incidence remains low and comparable to that associated with other induction agents.

引用

页码：236 / 239

页数：4

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