A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor

被引：41

作者：

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

Smith, Christopher D. ^{[1
]}

Tamborini, Lucia ^{[1
]}

Voica, Ana-Florina ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr ACS, Cambridge CB2 1EW, England

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 06期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/cc800070a

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.

引用

页码：851 / 857

页数：7

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