Limonoids from fruit of Melia toosendan and their cytotoxic activity

被引：78

作者：

Tada, K ^{[1
]}

Takido, M ^{[1
]}

Kitanaka, S ^{[1
]}

机构：

[1] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan

来源：

PHYTOCHEMISTRY | 1999年 / 51卷 / 06期

关键词：

Melia toosendan; Meliaceae; limonoid; acetal bridge limonoid; cytotoxic agent; toosendanal; 12-O-methylvolkensin; meliatoxin B-1; toosendanin; trichilin H;

D O I：

10.1016/S0031-9422(99)00115-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new limonoids, toosendanal and 12-O-methylvolkensin, were isolated from the fruits of Melia toosendan Sieb. et Zucc. along with three known limonoids, meliatoxin B-1, trichilin H, and toosendanin. The structures of the new limonoids were established by spectroscopic methods, with toosendanal having C-1/C-29 and C-19/C-29 acetal bridges. Both meliatoxin B-1 and toosendanin exhibit cytotoxic activity against KB cells. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：787 / 791

页数：5

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