Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy

被引：45
作者：
Fasching, P. A. [1 ]
Kollmannsberger, B. [1 ]
Strissel, P. L. [1 ]
Niesler, B. [2 ]
Engel, J. [1 ]
Kreis, H. [1 ]
Lux, M. P. [1 ]
Weihbrecht, S. [1 ]
Lausen, B. [3 ]
Bani, M. R. [1 ]
Beckmann, M. W. [1 ]
Strick, R. [1 ]
机构：
[1] Erlangen Univ Hosp, Univ Breast Ctr Franconia, D-91054 Erlangen, Bavaria, Germany
[2] Univ Heidelberg, Dept Human Mol Genet, Heidelberg, Germany
[3] Univ Erlangen Nurnberg, Inst Med Informat Biometry & Epidemiol, Erlangen, Germany
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2008年 / 134卷 / 10期
关键词：
chemotherapy-induced nausea and vomiting (CINV); single nucleotide polymorphism; breast cancer; 5-HT(3)R; pharmacogenomics; HTR3C;
D O I：
10.1007/s00432-008-0387-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to correlate chemotherapy-induced nausea and vomiting (CINV) with commonly occurring single nucleotide polymorphisms (SNP) in the 5-hydroxytryptamine receptor 3 genes (HTR3). Women with breast cancer without previous chemotherapy were eligible for this prospective study. All patients received epirubicin, with or without cyclophosphamide, and preventive medication with ondansetron and dexamethasone. The patients documented every vomiting event on an hourly basis. Real-time polymerase chain reaction (PCR) analysis was performed for the following nonsynonymous SNPs: p.Y129S (HTR3B), p.K163N (HTR3C) and p.A405G (HTR3C). The overall proportion of patients (total n = 110) who reported vomiting in the first 24 h after chemotherapy was 31.8%. The variant genotype of K163N (HTR3C) was associated with vomiting, which occurred in 50.0% (P = 0.009). Polymorphisms in the HTR3C gene could serve as a predictive factor for CINV in patients undergoing moderately emetogenic chemotherapy.
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收藏
页码：1079 / 1086
页数：8
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