Small-Molecule Lipid-Bilayer Anion Transporters for Biological Applications

被引：169
作者：
Busschaert, Nathalie [1 ]
Gale, Philip A. [1 ]
机构：
[1] Univ Southampton, Southampton SO17 1BJ, Hants, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 05期
关键词：
anions; hydrogen bonding; ion transport; membranes; supramolecular chemistry; FACILITATED PHOSPHOLIPID TRANSLOCATION; CHLORIDE TRANSPORT; FLIP-FLOP; CELL-MEMBRANES; TRANSMEMBRANE TRANSPORT; SYNTHETIC TRANSLOCASES; BICARBONATE SECRETION; CYSTIC-FIBROSIS; PI SLIDES; CHANNELS;
D O I：
10.1002/anie.201207535
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The development of small-molecule lipid-bilayer anion transporters for potential future use in channel replacement therapy for the treatment of diseases caused by dysregulation of anion transport (such as cystic fibrosis), and in treating cancer by perturbing chemical gradients within cells, thus triggering apoptosis, is an area of intense current interest. This Minireview looks at recent developments in the design of small-molecule transmembrane anion transporters and focuses on the progress so far in employing these compounds in biological systems.
引用
收藏
页码：1374 / 1382
页数：9
相关论文
共 72 条
[1]   Structurally simple lipid bilayer transport agents for chloride and bicarbonate [J].
Andrews, Natalie J. ;
Haynes, Cally J. E. ;
Light, Mark E. ;
Moore, Stephen J. ;
Tong, Christine C. ;
Davis, Jeffery T. ;
Harrell, William A., Jr. ;
Gale, Philip A. .
CHEMICAL SCIENCE, 2011, 2 (02) :256-260
[2]  
Ashcroft F. M., 2000, ION CHANNELS DIS
[3]   Anion Complexation and Transport by Isophthalamide and Dipicolinamide Derivatives: DNA Plasmid Transformation in E. coli [J].
Atkins, Jason L. ;
Patel, Mohit B. ;
Daschbach, Megan M. ;
Meisel, Joseph W. ;
Gokel, George W. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (33) :13546-13549
[4]   Monoacylglycerols as transmembrane Cl- anion transporters [J].
Bahmanjah, Soheila ;
Zhang, Ning ;
Davis, Jeffery T. .
CHEMICAL COMMUNICATIONS, 2012, 48 (37) :4432-4434
[5]   Structure/activity study of tris(2-aminoethyl)amine-derived translocases for phosphatidylcholine [J].
Boon, JM ;
Lambert, TN ;
Smith, BD ;
Beatty, AM ;
Ugrinova, V ;
Brown, SN .
JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (07) :2168-2174
[6]   Facilitated phospholipid translocation across vesicle membranes using low-molecular-weight synthetic flippases [J].
Boon, JM ;
Smith, BD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (50) :11924-11925
[7]   Facilitated phosphatidylserine (PS) flip-flop and thrombin activation using a synthetic PS scramblase [J].
Boon, JM ;
Lambert, TN ;
Sisson, AL ;
Davis, AP ;
Smith, BD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (27) :8195-8201
[8]   Facilitated phosphatidylcholine flip-flop across erythrocyte membranes using low molecular weight synthetic translocases [J].
Boon, JM ;
Smith, BD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (26) :6221-6226
[9]  
BowmanJames K, 2012, ANION COORDINATION CHEMISTRY, P1
[10]   Steroid-based anion receptors and transporters [J].
Brotherhood, Peter R. ;
Davis, Anthony P. .
CHEMICAL SOCIETY REVIEWS, 2010, 39 (10) :3633-3647
12345678