Click and Click-Inspired Chemistry for the Design of Sequence-Controlled Polymers

被引:85
作者
Martens, Steven [1 ]
Holloway, Joshua O. [1 ]
Du Prez, Filip. E. [1 ]
机构
[1] Univ Ghent, Polymer Chem Res Grp, Dept Organ & Macromol Chem, Ctr Macromol Chem CMaC, Krijgslaan 281 S4 Bis, B-9000 Ghent, Belgium
基金
欧盟地平线“2020”;
关键词
click chemistry; CuAAC; Diels-Alder; sequence-controlled structures; thiol-X; SOLID-PHASE SYNTHESIS; ITERATIVE EXPONENTIAL-GROWTH; SELECTIVE RADICAL-ADDITION; HYBRID BLOCK-COPOLYMERS; AZIDE-ALKYNE FRAGMENTS; THIOL-ENE; ONE-POT; DEFINED OLIGOMERS; MODULAR APPROACH; SIDE-CHAIN;
D O I
10.1002/marc.201700469
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
During the previous decade, many popular chemical reactions used in the area of "click" chemistry and similarly efficient "click-inspired" reactions have been applied for the design of sequence-defined and, more generally, sequence-controlled structures. This combination of topics has already made quite a significant impact on scientific research to date and has enabled the synthesis of highly functionalized and complex oligomeric and polymeric structures, which offer the prospect of many exciting further developments and applications in the near future. This minireview highlights the fruitful combination of these two topics for the preparation of sequence-controlled oligomeric and macromolecular structures and showcases the vast number of publications in this field within a relatively short span of time. It is divided into three sections according to the click-(inspired) reaction that has been applied: copper-catalyzed azide-alkyne cycloaddition, thiol-X, and related thiolactone-based reactions, and finally Diels-Alder-chemistry-based routes are outlined, respectively.
引用
收藏
页数:15
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