Long-term prevention of skeletal complications by pamidronate in a patient with bone metastasis from endometrial carcinoma: A case report

Introduction. Bisphosphonates are all effective treatment for bone metastases from breast cancer. However, it is unclear whether they are effective for bone metastases from endometrial carcinoma. Case. A 70-year-old woman previously treated for endometrial carcinoma was referred to our hospital due to osteolytic destruction of the left ischial tuberosity. Technetium-99m-HMDP bone scintigraphy revealed abnormal uptake in the ischium. Biopsy revealed a metastatic bone tumor, but computed tomography scans did not show general metastatic spread. The patient received intravenous administration of pamidronate and three cycles of chemotherapy (epirubicin + paclitaxel + carboplatin). Three years later, the bone lesion showed prominent sclerotic changes with no evidence of disease recurrence radiologically. Conclusion. Pamidronate may prevent skeletal complications in selected patients with bone metastasis due to endometrial carcinoma. (c) 2005 Elsevier Inc. All rights reserved.