Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB

被引：30

作者：

Sun, Yujin ^{[1
,2
]}

Kim, Hoe Suk ^{[1
]}

Saw, Phei Er ^{[3
]}

Jon, Sangyong ^{[3
]}

Moon, Woo Kyung ^{[1
]}

机构：

[1] Seoul Natl Univ Hosp, Dept Radiol, Seoul 110744, South Korea

[2] Yanbian Univ Hosp, Dept Radiol, Yanji 133000, Jilin Province, Peoples R China

[3] Korea Adv Inst Sci & Technol, Taejon 305701, South Korea

来源：

ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 11期

关键词：

aptides; breast cancer; stem cells; fibronectin; liposomes; RNA; targeted cancer therapy; INITIATING CELLS; NANOPARTICLES; ANGIOGENESIS; EXPRESSION; RESISTANCE; CARCINOMA; ADHESION; MARKER; DOMAIN;

D O I：

10.1002/adhm.201500190

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Targeted therapy for breast cancer stem cell (BCSC): A novel liposomal system (APTEDB-LS-siRNAEDB) that enables simultaneous targeting and knockdown of extra domain B of fibronectin (EDB-FN) shows potent therapeutic efficacy in the BCSC-derived tumors in vivo. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1675 / 1680

页数：6

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