Splanchnic vein thrombosis associated with myeloproliferative neoplasms

被引：15

作者：

Tremblay, Douglas ^{[1
,5
]}

Winters, Adam ^{[2
]}

Beckman, Joan D. ^{[3
]}

Naymagon, Leonard ^{[1
]}

Patel, Rahul ^{[4
]}

Mascarenhas, John ^{[1
]}

Schiano, Thomas D. ^{[2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY USA

[2] Icahn Sch Med Mt Sinai, Recanati Miller Transplantat Inst, Div Liver Dis, New York, NY USA

[3] Univ Minnesota, Div Hematol Oncol & Transplantat, Med Sch, Minneapolis, MN USA

[4] Icahn Sch Med Mt Sinai, Div Intervent Radiol, New York, NY USA

[5] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Myeloproliferat Disorders Program, Div Hematol Oncol, One Gustave L Levy Pl,Box 1079, New York, NY 10029 USA

来源：

THROMBOSIS RESEARCH | 2022年 / 218卷

关键词：

Splanchnic vein; Thrombosis; Myeloproliferative; Polycythemia vera; Essential thrombocythemia; Myelofibrosis; BUDD-CHIARI-SYNDROME; VENOUS THROMBOSIS; ENDOTHELIAL-CELLS; JAK2; MUTATION; MYELOFIBROSIS; DIAGNOSIS; JAK2V617F; RISK; PREVALENCE; IMPACT;

D O I：

10.1016/j.thromres.2022.08.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Splanchnic vein thrombosis (SVT) in the setting of myeloproliferative neoplasm (MPN) is a unique clinical entity that requires close interdisciplinary coordination for proper diagnosis and management. The pathobiology of MPN-SVT is not fully understood, but recent developments have revealed the central role of endothelial cells. In this multidisciplinary review, we summarize the epidemiology of MPN-SVT and then critically evaluate the pathogenic features of this complication, with a focus on endothelial cell biology. We then discuss diagnostic considerations, including imaging modalities and MPN-specific investigations. Finally, we critically review the evidence supporting clinical management of MPN-SVT, including anticoagulation, interventional radiology procedures, MPN-related therapies, and liver transplantation. We conclude that further studies are needed to improve our understanding of MPN-SVT and the outcomes of patients with this debilitating complication.

引用

页码：8 / 16

页数：9

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