Intra-host Trypanosoma cruzi strain dynamics shape disease progression: the missing link in Chagas disease pathogenesis

被引：0

作者：

Dumonteil, Eric ^{[1
,2
]}

Desale, Hans ^{[1
,2
]}

Tu, Weihong ^{[1
,2
]}

Hernandez-Cuevas, Nora ^{[3
]}

Shroyer, Monica ^{[4
]}

Goff, Kelly ^{[5
]}

Marx, Preston A. ^{[1
,2
,5
]}

Herrera, Claudia ^{[1
,2
]}

机构：

[1] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA 70118 USA

[2] Tulane Univ, Vector Borne & Infect Dis Res Ctr, New Orleans, LA 70118 USA

[3] Univ Autonoma Yucatan, Ctr Invest Reg Dr Hideyo Noguchi, Lab Parasitol, Merida, Yucatan, Mexico

[4] Tulane Univ, Tulane Natl Primate Res Ctr, Div Vet Med, Covington, LA USA

[5] Tulane Univ, Tulane Natl Primate Res Ctr, Div Microbiol, Covington, LA USA

来源：

MICROBIOLOGY SPECTRUM | 2023年

关键词：

strain interactions; host-parasite relationship; intracellular parasites; competition; pathogenesis;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chronic Chagasic cardiomyopathy develops years after infection in 20-40% of patients, but disease progression is poorly understood. Here, we assessed Trypanosoma cruzi parasite dynamics and pathogenesis over a 2.5-year period in naturally infected rhesus macaques. Individuals with better control of parasitemia were infected with a greater diversity of parasite strains compared to those with increasing parasitemia over time. Also, the in vivo parasite multiplication rate decreased with increasing parasite diversity, suggesting competition among strains or a stronger immune response in multiple infections. Significant differences in electrocardiographic (ECG) profiles were observed in Chagasic macaques compared to uninfected controls, suggesting early conduction defects, and changes in ECG patterns over time were observed only in macaques with increasing parasitemia and lower parasite diversity. Disease progression was also associated with plasma fibronectin degradation, which may serve as a biomarker. These data provide a novel framework for the understanding of Chagas disease pathogenesis, with parasite diversity shaping disease progression.

引用

页数：21