DIFFERENT EXPRESSION PATTERNS OF PHACTR FAMILY MEMBERS IN NORMAL AND INJURED MOUSE BRAIN

被引：20

作者：

Kim, J. Y. ^{[1
]}

Choi, S. Y. ^{[1
]}

Moon, Y. ^{[2
]}

Kim, H. J. ^{[1
]}

Chin, J. H. ^{[1
]}

Kim, H. ^{[1
]}

Sun, W. ^{[1
]}

机构：

[1] Korea Univ, Coll Med, Dept Anat, Seoul 136705, South Korea

[2] Seoul Natl Univ, Coll Nat Sci, Sch Biol Sci, Brain & Neuroendocrine Lab, Seoul 151742, South Korea

来源：

NEUROSCIENCE | 2012年 / 221卷

基金：

新加坡国家研究基金会;

关键词：

Phactrs; neural stem/progenitor cell; traumatic brain injury; in situ hybridization; PROTEIN PHOSPHATASE 1; PROGRAMMED CELL-DEATH; NITRIC-OXIDE SYNTHASE; NEURAL STEM-CELLS; REACTIVE ASTROCYTES; HIPPOCAMPAL CONTINUATION; INDUSIUM GRISEUM; ADULT BRAIN; GLIOSIS; RAT;

D O I：

10.1016/j.neuroscience.2012.06.059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Phosphatase and actin regulators (Phactrs) are a novel family of proteins expressed in the brain, and they exhibit both strong modulatory activity of protein phosphatase 1 and actin-binding activity. Phactrs are comprised of four family members (Phactr1-4), but their detailed expression patterns during embryonic and postnatal development are not well understood. We found that these family members exhibit different spatiotemporal mRNA expression patterns. Phactr4 mRNA was found in neural stem cells in the developing and adult brains, whereas Phactr1 and 3 appeared to be expressed in post-mitotic neurons. Following traumatic brain injury which promotes neurogenesis in the neurogenic region and gliogenesis in the injury penumbra, the mRNA expression of phactr2 and 4 was progressively increased in the injury penumbra, and phactr4 mRNA and protein induction was observed in reactive astrocytes. These differential expression patterns of phactrs imply specific functions for each protein during development, and the importance of Phactr4 in the reactive gliosis following brain injury. (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：37 / 46

页数：10

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