The development of denosumab for the treatment of diseases of bone loss and cancer-induced bone destruction

被引：32

作者：

Goessl, Carsten ^{[1
]}

Katz, Leonid ^{[1
]}

Dougall, William C. ^{[2
]}

Kostenuik, Paul J. ^{[1
]}

Zoog, Holly Brenza ^{[1
]}

Braun, Ada ^{[1
]}

Dansey, Roger ^{[1
]}

Wagman, Rachel B. ^{[1
]}

机构：

[1] Amgen Inc, Thousand Oaks, CA 91320 USA

[2] Amgen Inc, Seattle, WA USA

来源：

PHARMACEUTICAL SCIENCE TO IMPROVE THE HUMAN CONDITION: PRIX GALIEN 2011 | 2012年 / 1263卷

关键词：

denosumab; RANKL; postmenopausal osteoporosis; bone metastases; OSTEOCLAST DIFFERENTIATION FACTOR; ANDROGEN-DEPRIVATION THERAPY; KAPPA-B LIGAND; POSTMENOPAUSAL WOMEN; BREAST-CANCER; PROSTATE-CANCER; ZOLEDRONIC ACID; MINERAL DENSITY; OSTEOPROTEGERIN LIGAND; RECEPTOR ACTIVATOR;

D O I：

10.1111/j.1749-6632.2012.06674.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Denosumab is a fully human monoclonal antibody against RANK ligand (RANKL), an essential cytokine for the formation, function, and survival of osteoclasts. The role of excessive RANKL as a contributor to conditions characterized by bone loss or bone destruction has been well studied. With its novel mechanism of action, denosumab offers a significant advance in the treatment of postmenopausal osteoporosis; bone loss associated with hormone ablation therapy in women with breast cancer and men with prostate cancer; and the prevention of skeletal-related events in patients with bone metastases from solid tumors by offering clinical benefit to these patients in need.

引用

页码：29 / 40

页数：12

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