Favipiravir (T-705) inhibits in vitro norovirus replication

被引：114
作者：
Rocha-Pereira, J. [2 ,3 ]
Jochmans, D. [1 ]
Dallmeier, K. [1 ]
Leyssen, P. [1 ]
Nascimento, M. S. J. [2 ,3 ]
Neyts, J. [1 ]
机构：
[1] Univ Leuven KU Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
[2] Univ Porto, Fac Farm, Dept Ciencias Biol, Microbiol Lab, P-4050313 Oporto, Portugal
[3] Univ Porto CEQUIMED UP, Ctr Quim Med, P-4050313 Oporto, Portugal
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 424卷 / 04期
关键词：
Norovirus; Antiviral activity; T-705; RNA-dependent RNA polymerase; ORALLY-ADMINISTERED T-705; VIRUS-INFECTION; VIVO ACTIVITIES; EFFICACY; MODEL; COMPOUND; DISEASE;
D O I：
10.1016/j.bbrc.2012.07.034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Human noroviruses are the primary cause of foodborne gastroenteritis. Potent and safe inhibitors are needed for the treatment/prophylaxis of norovirus infections. We demonstrate that Favipiravir [T-705, a drug in advanced clinical development for the treatment of infections with the influenza virus] inhibits in vitro murine norovirus replication. Time-of-drug addition studies reveal that T-705 exerts its activity at a time-point that coincides with onset of viral RNA synthesis, which is in line with the viral polymerase as the presumed target. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：777 / 780
页数：4
相关论文
共 23 条
[1]   Detection of murine norovirus 1 by using plaque assay, transfection assay, and real-time reverse transcription-PCR before and after heat exposure [J].
Baert, Leen ;
Wobus, Christiane E. ;
Van Coillie, Els ;
Thackray, Larissa B. ;
Debevere, Johan ;
Uyttendaele, Mieke .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2008, 74 (02) :543-546
[2]   Norovirus in a Dutch tertiary care hospital (2002-2007): frequent nosocomial transmission and dominance of Glib strains in young children [J].
Beersma, M. F. C. ;
Schutten, M. ;
Vennema, H. ;
Hartwig, N. G. ;
Mes, T. H. M. ;
Osterhaus, A. D. M. E. ;
van Doornum, G. J. J. ;
Koopmans, M. .
JOURNAL OF HOSPITAL INFECTION, 2009, 71 (03) :199-205
[3]   Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line [J].
Chang, Kyeong-Ok ;
Sosnovtsev, Stanislav V. ;
Belliot, Gael ;
King, Adriene D. ;
Green, Kim Y. .
VIROLOGY, 2006, 353 (02) :463-473
[4]   Mechanism of action of T-705 against influenza virus [J].
Furuta, Y ;
Takahashi, K ;
Kuno-Maekawa, M ;
Sangawa, H ;
Uehara, S ;
Kozaki, K ;
Nomura, N ;
Egawa, H ;
Shiraki, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (03) :981-986
[5]   In vitro and in vivo activities of anti-influenza virus compound T-705 [J].
Furuta, Y ;
Takahashi, K ;
Fukuda, Y ;
Kuno, M ;
Kamiyama, T ;
Kozaki, K ;
Nomura, N ;
Egawa, H ;
Minami, S ;
Watanabe, Y ;
Narita, H ;
Shiraki, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (04) :977-981
[6]   T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections [J].
Furuta, Yousuke ;
Takahashi, Kazumi ;
Shiraki, Kimiyasu ;
Sakamoto, Kenichi ;
Smee, Donald F. ;
Barnard, Dale L. ;
Gowen, Brian B. ;
Julander, Justin G. ;
Morrey, John D. .
ANTIVIRAL RESEARCH, 2009, 82 (03) :95-102
[7]   CURRENT CONCEPTS Norovirus Gastroenteritis [J].
Glass, Roger I. ;
Parashar, Umesh D. ;
Estes, Mary K. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (18) :1776-1785
[8]   In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections [J].
Gowen, Brian B. ;
Wong, Min-Hui ;
Jung, Kie-Hoon ;
Sanders, Andrew B. ;
Mendenhall, Michelle ;
Bailey, Kevin W. ;
Furuta, Yousuke ;
Sidwell, Robert W. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (09) :3168-3176
[9]   Treatment of Late Stage Disease in a Model of Arenaviral Hemorrhagic Fever: T-705 Efficacy and Reduced Toxicity Suggests an Alternative to Ribavirin [J].
Gowen, Brian B. ;
Smee, Donald F. ;
Wong, Min-Hui ;
Hall, Jeffery O. ;
Jung, Kie-Hoon ;
Bailey, Kevin W. ;
Stevens, John R. ;
Furuta, Yousuke ;
Morrey, John D. .
PLOS ONE, 2008, 3 (11)
[10]  
Green KY., 2007, FIELDS VIROLOGY, V5th, P949
123