TNF-A-308 G/A POLYMORPHISM AND SUSCEPTIBILITY TO TUBERCULOSIS IN AZERI POPULATION OF IRAN

被引：2

作者：

Ghorghanlu, Sajjad ^{[1
]}

Asgharzadeh, Mohammad ^{[2
]}

Samadi-Kafil, Hossein ^{[3
]}

Khaki-Khatibi, Fatemeh ^{[4
]}

Rashedi, Jalil ^{[2
]}

Poor, Behroz Mahdavi ^{[2
]}

Moaddab, Seyyed Reza ^{[2
]}

Pourostadi, Mahya ^{[5
]}

机构：

[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Biotechnol Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Paramed Fac, Biotechnol Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Fac Med, Tabriz, Iran

[4] Tabriz Univ Med Sci, Dept Clin Biochem, Fac Med, Tabriz, Iran

[5] Tabriz Univ Med Sci, Hematol Oncol Res Ctr, Tabriz, Iran

来源：

GENETIKA-BELGRADE | 2016年 / 48卷 / 03期

关键词：

association; single nucleotide polymorphism; tuberculosis; tumor necrosis factor-alpha; susceptibility; ALPHA GENE POLYMORPHISMS; TNF-ALPHA; PROMOTER POLYMORPHISM; INTERLEUKIN-10; ASSOCIATION; INFECTION; IL-10;

D O I：

10.2298/GENSR1603819G

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Single nucleotide polymorphisms (SNPs) in cytokine genes may alter the level and function of secreted cytokine; therefore, SNPs can influence the immune response. The aim of the present study was to determine the association of TNF-alpha -308G/A single nucleotide polymorphism in tuberculosis patients in the Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in the promoter region was genotyped by using the allele-specific PCR method in 200 healthy controls and 124 tuberculosis patients. The distribution of allele frequencies for TNF-alpha -308G/A polymorphism between control and tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5). Furthermore, no statistically significant association was found between TNF-alpha -308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our results suggest that TNF-alpha -308G/A polymorphism has no measurable effect on the development of tuberculosis in Azeri population of Iran.

引用

页码：819 / 826

页数：8

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