TNF-A-308 G/A POLYMORPHISM AND SUSCEPTIBILITY TO TUBERCULOSIS IN AZERI POPULATION OF IRAN

被引：2
|
作者：
Ghorghanlu, Sajjad [1 ]
Asgharzadeh, Mohammad [2 ]
Samadi-Kafil, Hossein [3 ]
Khaki-Khatibi, Fatemeh [4 ]
Rashedi, Jalil [2 ]
Poor, Behroz Mahdavi [2 ]
Moaddab, Seyyed Reza [2 ]
Pourostadi, Mahya [5 ]
机构：
[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Biotechnol Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Paramed Fac, Biotechnol Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Fac Med, Tabriz, Iran
[4] Tabriz Univ Med Sci, Dept Clin Biochem, Fac Med, Tabriz, Iran
[5] Tabriz Univ Med Sci, Hematol Oncol Res Ctr, Tabriz, Iran
来源：
GENETIKA-BELGRADE | 2016年 / 48卷 / 03期
关键词：
association; single nucleotide polymorphism; tuberculosis; tumor necrosis factor-alpha; susceptibility; ALPHA GENE POLYMORPHISMS; TNF-ALPHA; PROMOTER POLYMORPHISM; INTERLEUKIN-10; ASSOCIATION; INFECTION; IL-10;
D O I：
10.2298/GENSR1603819G
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
Single nucleotide polymorphisms (SNPs) in cytokine genes may alter the level and function of secreted cytokine; therefore, SNPs can influence the immune response. The aim of the present study was to determine the association of TNF-alpha -308G/A single nucleotide polymorphism in tuberculosis patients in the Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in the promoter region was genotyped by using the allele-specific PCR method in 200 healthy controls and 124 tuberculosis patients. The distribution of allele frequencies for TNF-alpha -308G/A polymorphism between control and tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5). Furthermore, no statistically significant association was found between TNF-alpha -308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our results suggest that TNF-alpha -308G/A polymorphism has no measurable effect on the development of tuberculosis in Azeri population of Iran.
引用
收藏
页码：819 / 826
页数：8
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