Effect of ZrO2 additions on the crystallization, mechanical and biological properties of MgO-CaO-SiO2-P2O5-CaF2 bioactive glass-ceramics

被引：29
作者：
Li, H. C. [1 ,2 ]
Wang, D. G. [1 ,2 ]
Meng, X. G. [1 ,2 ]
Chen, C. Z. [1 ,2 ]
机构：
[1] Shandong Univ, Minist Educ, Key Lab Liquid Solid Struct Evolut & Proc Mat, Jinan 250061, Shandong, Peoples R China
[2] Shandong Univ, Sch Mat Sci & Engn, Jinan 250061, Shandong, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 118卷
关键词：
ZrO2; Glass-ceramic; Mechanical properties; Bioactivity; Biocompatibility; FRACTURE-TOUGHNESS; FORMING ABILITY; APATITE; HYDROXYAPATITE; COMPOSITES; BEHAVIOR; MICROSTRUCTURE; FLUORAPATITE; STRENGTH; TIO2;
D O I：
10.1016/j.colsurfb.2014.03.055
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A series of ZrO2 doped MgO-CaO-SiO2-P2O5-CaF2 bioactive glass-ceramics were obtained by sintering method. The crystallization behavior, phase composition, morphology and structure of glass-ceramics were characterized. The bending strength, elastic modulus, fracture toughness, micro-hardness and thermal expansion coefficient (TEC) of glass-ceramics were investigated. The in vitro bioactivity and cytotoxicity tests were used to evaluate the bioactivity and biocompatibility of glass-ceramics. The sedimentation mechanism and growth process of apatites on sample surface were discussed. The results showed that the mainly crystalline phases of glass-ceramics were Ca-5(PO4)(3)F (fluorapatite) and beta-CaSiO3 (beta-wollastonite). m-ZrO2 (monoclinic zirconia) declined the crystallization temperatures of glasses. t-ZrO2 (tetragonal zirconia) increased the crystallization temperature of Ca-5(PO4)(3)F and declined the crystallization temperature of beta-CaSiO3. t-ZrO2 greatly increased the fracture toughness, bending strength and micro-hardness of glass-ceramics. The nanometer apatites were induced on the surface of glass-ceramic after soaking 28 days in SBF (simulated body fluid), indicating the glass-ceramic has good bioactivity. The in vitro cytotoxicity test demonstrated the glass-ceramic has no toxicity to cell. (C) 2014 Elsevier B.V. All rights reserved.
引用
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页码：226 / 233
页数：8
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