The Anti-influenza Virus Effect of Phellinus igniarius Extract

被引:41
作者
Lee, Sangmoo [1 ,2 ]
Kim, Jin Il [1 ,2 ]
Heo, Jun [1 ,2 ]
Lee, Ilseob [1 ,2 ]
Park, Sehee [1 ,2 ]
Hwang, Min-Woong [1 ,2 ]
Bae, Joon-Yong [1 ,2 ]
Park, Mee Sook [1 ,2 ]
Park, Hyoung Jin [3 ]
Park, Man-Seong [1 ,2 ]
机构
[1] Hallym Univ, Dept Microbiol, Chunchon 200702, South Korea
[2] Hallym Univ, Ctr Med Sci Res, Coll Med, Chunchon 200702, South Korea
[3] Hallym Univ, MushMed Co LTD, Chunchon 200702, South Korea
基金
新加坡国家研究基金会;
关键词
antiviral; herbal; influenza; multi-drug; Phellinus igniarius; INFLUENZA-A VIRUS; MEDICINAL MUSHROOM; COMBINATION CHEMOTHERAPY; RECEPTOR SPECIFICITY; LINTEUS; POLYSACCHARIDE; HEMAGGLUTININ; OSELTAMIVIR; RESISTANCE; PROTEINS;
D O I
10.1007/s12275-013-3384-2
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multicomponent nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.
引用
收藏
页码:676 / 681
页数:6
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